Head‑to‑head assessment of [68Ga]Ga-DOTA-FAPI-04 PET/CT vs [18F]FDG PET/CT in fibroblastic tumors.
Head‑to‑head assessment of [68Ga]Ga-DOTA-FAPI-04 PET/CT vs [18F]FDG PET/CT in fibroblastic tumors.
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成纤维细胞肿瘤中 [68Ga]Ga-DOTA-FAPI-04 PET/CT 与 [18F]FDG PET/CT 的头对头评估。
DOI：
10.1016/j.ejrad.2022.110507
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发表时间：
2022-09
影响因子：
3.3
通讯作者：
Nan Li
中科院分区：
文献类型：
--
作者：
Annan Zhang;Xiangxi Meng;Yuan Yao;Xin Zhou;Yan Zhang;Nan Li
We aimed to evaluate [68GaGa-DOTA-FAPI-04 versus [18FFDG PET/CT in the application of fibroblastic tumors.Twenty participants with 6 subtypes of fibroblastic tumors prospectively underwent 18F-FDG and [68GaGa-DOTA-FAPI-04 PET/CT examinations to evaluate the lesions. PET/CT findings were confirmed by surgical pathology of fifteen participants, puncture biopsy of two participants, or imaging follow-up of three participants. Two independent sample t tests were used to compare the uptake of [18FFDG vs [68GaGa-DOTA-FAPI-04 in primary, recurrent and metastatic lesions. One-way ANOVA was used to compare the uptake of [18FFDG or [68GaGa-DOTA-FAPI-04 among primary, recurrent, and metastatic lesions. The uptake of [68GaGa-DOTA-FAPI-04 vs [18FFDG in different histopathological lesions was compared by two independent sample t tests.Twenty participants were confirmed to have 38 lesions. Although there was no significant difference in the detection of lesions between [68GaGa-DOTA-FAPI-04 and [18FFDG PET/CT (38 vs 36, p = 0.493), the uptake of [68GaGa-DOTA-FAPI-04 in lesions was significantly higher than that of [18FFDG (p < 0.001), including primary (p < 0.001), recurrent (p = 0.018) and metastatic (p < 0.001) lesions. The SUVmax of [68GaGa-DOTA-FAPI-04 in primary and recurrent lesions was higher than that in metastasis (p = 0.034 and p = 0.015, respectively). The SUVmax of [68GaGa-DOTA-FAPI-04 in primary and recurrent malignant lesions was significantly higher than that of the intermediate (p < 0.001). The SUVmax of [68GaGa-DOTA-FAPI-04 in one participant of recurrent SFT with 5 lesions was significantly lower after treatment than before treatment (p = 0.016).[68GaGa-DOTA-FAPI-04 outperformed [18FFDG PET/CT in displaying the primary, recurrent and metastatic lesions of fibroblastic tumors.
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影响因子：
8.4
作者：
Eisenhauer, E. A.;Therasse, P.;Verweij, J.
通讯作者：
Verweij, J.
DOI：
10.17116/hirurgia202008135
发表时间：
2020-01-01
期刊：
Khirurgiia
影响因子：
--
作者：
Salimov, Z M;Pikin, O V;Nikulin, K A
通讯作者：
Nikulin, K A
DOI：
10.1007/s00259-021-05273-8
发表时间：
2021-08
影响因子：
9.1
作者：
Kratochwil C;Giesel FL;Rathke H;Fink R;Dendl K;Debus J;Mier W;Jäger D;Lindner T;Haberkorn U
通讯作者：
Haberkorn U
影响因子：
7.5
作者：
Karanian, Marie;Perot, Gaelle;Neuville, Agnes
通讯作者：
Neuville, Agnes
影响因子：
11.2
作者：
Loh, Jia-Jian;Li, Tsz-Wai;Ma, Stephanie
通讯作者：
Ma, Stephanie