Exercise increases serum brain-derived neurotrophic factor in patients with major depressive disorder
Exercise increases serum brain-derived neurotrophic factor in patients with major depressive disorder
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运动增加抑郁症患者血清脑源性神经营养因子
DOI：
10.1016/j.jad.2017.03.034
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发表时间：
2017-06-01
影响因子：
6.6
通讯作者：
Kahl, K. G.
中科院分区：
文献类型：
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作者：
Kerling, A.;Kueck, M.;Kahl, K. G.
背景：脑源性神经营养因子（BDNF）参与了抑郁症（MDD）的发病机制。关于MDD患者运动治疗的现有数据不一致，运动对BDNF的影响指向增加或不变的BDNF浓度。然而，对非抑郁症患者的研究表明，有氧训练干预对静息外周BDNF浓度有显著影响。鉴于缺乏上述明确性，目前的研究旨在探讨持续运动对血清BDNF水平的影响，在指南为基础的治疗患者MDD.Methods：42抑郁症住院患者，并随机分为6周的结构化和监督的运动干预加治疗照常（EXERCISE，n=22），或治疗照常（TAU，n=20）。BDNF血清浓度进行了评估之前和之后的干预，在两个研究组与建立immunoassays.Results：血清BDNF略有下降，在TAU组，而有一个在运动组的BDNF水平的增加。有一个显着的时间x组的影响sBDNF（p=0.030）与重复的ANOVA测量年龄和BMI作为协变量，表明增加BDNF浓度的EXERCISE组相比，TAU.Limitations：虽然没有统计学差异，在抗抑郁药物之间的EXERCISE和TAU运动和运动对BDNF的影响的药物之间的潜在的相互作用不能被排除。性别不被认为是协变量在AN0VA.Conclusions：运动训练作为辅助标准指南为基础的治疗似乎有额外的影响，在人与MDD的BDNF血清浓度。我们的研究结果进一步证明了运动在治疗MDD中的有益作用。
Background: Brain derived neurotrophic factor (BDNF) has been implicated in the pathogenesis of major depressive disorder (MDD). Existing data on exercise treatment in people with MDD are inconsistent concerning the effect of exercise on BDNF pointing either to increased or unaltered BDNF concentrations. However, studies in non-depressed persons demonstrated a significant effect on resting peripheral BDNF concentrations in aerobic training interventions. Given the lack of clarity mentioned above, the current study aimed at examining the effect of adjunctive exercise on serum BDNF levels in guideline based treated patients with MDD.Methods: 42 depressed inpatients were included, and randomized either to a 6 week structured and supervised exercise intervention plus treatment as usual (EXERCISE, n=22), or to treatment as usual (TAU, n=20). BDNF serum concentrations were assessed before and after the intervention in both study groups with established immunoassays.Results: Serum BDNF slightly decreased in the TAU group, whilst there was an increase in BDNF levels in the exercise group. There was a significant time x group effect concerning sBDNF (p=0.030) with repeated ANOVA measures with age and BMI as covariates, suggesting an increase in BDNF concentrations in the EXERCISE group compared to TAU.Limitations: Though there was no statistic difference in the antidepressant medication between EXERCISE and TAU potential interactions between exercise and medication on the effects of exercise in BDNF cannot be excluded. Gender was not considered as a covariate in ANOVA due to the small number of objects.Conclusions: Exercise training given as adjunct to standard guideline based treatment appears to have additional effects on BDNF serum concentrations in people with MDD. Our results add further evidence to the beneficial effects of exercise in the treatment of MDD.