Ethanol consumption and place-preference conditioning in the alcohol-preferring C57BL/6 mouse: Relationship with motor activity patterns
Ethanol consumption and place-preference conditioning in the alcohol-preferring C57BL/6 mouse: Relationship with motor activity patterns
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DOI：
10.1097/00000374-199904001-00015
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发表时间：
1999-04-01
影响因子：
3.2
通讯作者：
Tavernetti, M
中科院分区：
文献类型：
--
作者：
Nocjar, C;Middaugh, LD;Tavernetti, M
在未接受药物和乙醇预暴露的雌性和雄性 C57BL/6J (C57) 小鼠中进行乙醇位置偏好调节 (PC)，以评估环境线索在与乙醇给药相关时是否可以为偏好乙醇的动物产生积极的激励价值。经过 12 天的间歇性自由选择乙醇和/或水自我给药后，小鼠在放入其非首选 PC 室前 5 分钟接受 8 次乙醇注射（1.75 g/kg/ip），并在其首选室中接受 8 次盐水注射。对照小鼠在其偏好和非偏好的室中接受八次盐水注射（20ml/kg）。两种性别的小鼠都产生了强烈的乙醇PC。相关分析表明，对于有过饮酒经历的小鼠来说，乙醇 PC 的强度与消耗的乙醇量呈负相关，无论性别如何。此外，根据性别和之前的乙醇饮用经验，乙醇 PC 与初始基线运动活动、对乙醇的初始运动反应或对乙醇的运动反应的快速变化存在差异相关。因此，正如当前成瘾理论所表明的那样，介导乙醇奖赏和运动活动的神经系统之间可能存在复杂的关系。
Ethanol place-preference conditioning (PC) was conducted in drug-naive and ethanol pre-exposed female and male C57BL/6J (C57) mice to assess whether environmental cues can develop positive incentive value for ethanol-preferring animals when associated with administration of ethanol. After 12 days episodic access to free-choice ethanol and/or water self-administration, mice received eight ethanol injections (1.75 g/kg/ip) 5 min before placement in their nonpreferred PC chamber and eight saline injections paired with their preferred chamber. Control mice received eight saline injections (20 ml/kg) in both their preferred and nonpreferred chambers. Mice of both sexes developed strong ethanol PC. Correlational analysis indicated that the strength of ethanol PC for mice with a prior ethanol drinking experience was inversely related to the amount of ethanol consumed regardless of gender. Furthermore, depending on gender and previous ethanol drinking experience, ethanol PC was differentially related to initial baseline motor activity, the initial motor response to ethanol, or rapid change in the motor response to ethanol. Thus, a complicated relationship between neural systems that mediate ethanol reward and motor activity may exist as suggested by current addiction theory.