Predictors of adherence among Alzheimer's disease patients receiving oral therapy
Predictors of adherence among Alzheimer's disease patients receiving oral therapy
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DOI：
10.1185/03007995.2010.493788
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发表时间：
2010-08-01
影响因子：
2.3
通讯作者：
Zarotsky, Victoria
中科院分区：
文献类型：
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作者：
Borah, Bijan;Sacco, Patricia;Zarotsky, Victoria
目标：治疗效果取决于按处方用药，坚持治疗对于阿尔茨海默病（AD）患者从治疗中获得最佳益处至关重要。本研究的目的是调查与坚持AD oral medicines.Methods：这一回顾性索赔分析确定AD患者谁开始口服AD治疗（利斯的明，多奈哌齐，加兰他敏，或美金刚）2006年1月1日至2007年12月31日，从一个大的美国健康计划。在6个月索引前期间评估患者基线特征;在索引后1年期间评估结局。药丸负担以每天独特的药物单位计数来衡量。依从性通过药物持有率（MPR）来衡量，MPR >= 80%定义为依从性。多变量logistic回归被用来评估潜在的协变量如何影响遵守probability.Results：共3091 AD患者（36%男性，平均年龄80 [8.25 SD]）被确定。只有58%的患者坚持口服AD药物。与575岁的患者相比，≥ 86岁的患者可能更依从（OR 1.401，p
Objectives:Treatment effectiveness depends upon administering medications as prescribed, and adherence is critical for Alzheimer's disease (AD) patients to receive optimal benefit from therapy. The objective of this study was to investigate factors associated with adherence to AD oral medications.Methods:This retrospective claims analysis identified AD patients who initiated oral AD therapy (rivastigmine, donepezil, galantamine, or memantine) between January 1, 2006 and December 31, 2007 from a large US health plan. Patient baseline characteristics were assessed during the 6-month pre-index period; outcomes were assessed during the 1-year post-index period. Pill burden was measured as a count of unique units of medication/day. Adherence was measured by medication possession ratio (MPR), with MPR >= 80% defined as adherent. Multivariate logistic regression was used to assess how potential covariates affect adherence probability.Results:A total of 3091 AD patients (36% male; mean age 80 [8.25 SD]) were identified. Only 58% of patients were adherent to oral AD medications. Compared to patients 575 years, patients >= 86 years were likely to be more adherent (OR 1.401, p