Crohn's Disease Susceptibility Genes are Associated With Leprosy in the Vietnamese Population
Crohn's Disease Susceptibility Genes are Associated With Leprosy in the Vietnamese Population
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DOI：
10.1093/infdis/jis588
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发表时间：
2012-12-01
影响因子：
6.4
通讯作者：
Alcais, Alexandre
中科院分区：
文献类型：
--
作者：
Grant, Audrey V.;Alter, Andrea;Alcais, Alexandre
一项在中国麻风患者中进行的全基因组关联研究在6个位点的16个单核苷酸多态性（SNPs）中检测到关联信号，其中4个与NOD 2信号通路相关，是克罗恩病的易感位点。在这里，我们研究了这16个SNPs作为潜在的麻风易感因素在474个越南麻风单纯型家庭。我们在越南复制了HLA-DR-DQ、RIPK 2、CCDC 122-LACC 1和NOD 2的SNPs作为麻风易感因素。这些结果证实了克罗恩病和麻风病的遗传控制有惊人的重叠。
A genomewide association study in Chinese patients with leprosy detected association signals in 16 single-nucleotide polymorphisms (SNPs) belonging to 6 loci, of which 4 are related to the NOD2 signaling pathway and are Crohn's disease susceptibility loci. Here, we studied these 16 SNPs as potential leprosy susceptibility factors in 474 Vietnamese leprosy simplex families. We replicated SNPs at HLA-DR-DQ, RIPK2, CCDC122-LACC1, and NOD2 as leprosy susceptibility factors in Vietnam. These results validated the striking overlap in the genetic control of Crohn's disease and leprosy.