Prolonged survival of neoplastic meningitis from breast cancer with letrozole and intrathecal methotrexate: a case report
Prolonged survival of neoplastic meningitis from breast cancer with letrozole and intrathecal methotrexate: a case report
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DOI：
10.1007/s11060-010-0268-8
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发表时间：
2011-02-01
影响因子：
3.9
通讯作者：
Kalofonos, Haralabos
中科院分区：
文献类型：
--
作者：
Peroukides, Stavros;Onyenadum, Adimchi;Kalofonos, Haralabos
乳腺癌引起的肿瘤性脑膜炎预后差，生存期短。治疗是基于鞘内给药化疗药物，颅或颅脊髓放射治疗和全身化疗。在本报告中，我们描述了一例乳腺癌肿瘤性脑膜炎的女性患者，她对来曲唑联合鞘内甲氨蝶呤产生了极好的反应，导致长期生存超过36个月。根据本病例报告的发现，我们建议在标准治疗方法中加入来曲唑可能对一些患者有益。
Neoplastic meningitis from breast cancer has a dismal prognosis and short survival. Treatment is based on the intrathecal administration of chemotherapeutic agents, cranial or craniospinal radiotherapy, and systemic chemotherapy. In this report we describe the case of a woman with neoplastic meningitis from breast carcinoma who developed an excellent response to letrozole combined with intrathecal methotrexate, resulting in long-term survival of more than 36 months. Based on the findings of this case report, we suggest that addition of letrozole to the standard therapeutic approach may be beneficial for some patients.