Racial differences in levels of serum lipids and effects of exposure to persistent organic pollutants on lipid levels in residents of Anniston, Alabama
Racial differences in levels of serum lipids and effects of exposure to persistent organic pollutants on lipid levels in residents of Anniston, Alabama
复制标题
DOI：
10.1016/j.envint.2014.07.022
复制
发表时间：
2014-12-01
影响因子：
11.8
通讯作者：
Carpenter, David O.
中科院分区：
文献类型：
--
作者：
Aminov, Zafar;Haase, Richard;Carpenter, David O.
血脂水平是心血管疾病的主要危险因素。除了饮食、运动、遗传、年龄和种族外，持久性有机污染物（POPs）的血清浓度也会影响血脂浓度。我们调查了35种多氯联苯（PCB）同系物和9种有机氯农药的空腹浓度与总血脂、总胆固醇、低密度脂蛋白（LDL）胆固醇、高密度脂蛋白（HDL）胆固醇和甘油三酯的关系，研究对象为525名未服用任何降脂药物的阿拉巴马州安尼斯顿白人和非裔美国人。在模型1中，对年龄、年龄二次元、性别、BMI、饮酒、吸烟和运动进行了调整，而在模型2中，对其他持久性有机污染物进行了额外的调整。与白种人相比，非裔美国人的总脂质和甘油三酯水平较低，高密度脂蛋白胆固醇浓度较高，但多氯联苯和农药浓度较高。与总多氯联苯相比，总杀虫剂与血脂升高的相关性更强，非裔美国人的相关性更强。在调整其他持久性有机污染物后，两种种族的总DDTs与血脂没有相关性，而六氯苯（HCB）在两种种族中都表现出最强的正相关性。脂质谱、持久性有机污染物浓度的种族差异以及持久性有机污染物浓度与血脂之间的关联与心血管疾病发病率的种族差异有关。(C) 2014 Elsevier Ltd.版权所有。
Serum lipid levels are major risk factors for cardiovascular disease. In addition to diet, exercise, genetics, age and race, serum concentrations of persistent organic pollutants (POPs) influence concentrations of serum lipids. We investigated associations between fasting concentrations of 35 polychlorinated biphenyl (PCB) congeners and nine organochlorine pesticides in relation to total serum lipids, total cholesterol, low-density lipoprotein (LDL) cholesterol, high density lipoprotein (HDL) cholesterol and triglycerides in 525 Caucasian and African American residents of Anniston, Alabama, who were not on any lipid-lowering medication. In Model 1, data were adjusted for age, age quadratic, gender, BMI, alcohol consumption, smoking and exercise, while in Model 2, additional adjustment was done for other POPs. As compared to Caucasians, African Americans had lower levels of total lipids and triglycerides with higher concentrations of HDL cholesterol, but higher concentrations of PCBs and pesticides. Total pesticides were more strongly associated with elevations in serum lipids than were total PCBs, and the associations were stronger in African Americans. Total DDTs were not associated with serum lipids after adjustment for other POPs in either racial group, while the strongest positive associations were seen for hexachlorobenzene (HCB) in both racial groups. Racial differences in lipid profiles, concentrations of POPs and associations between POP concentrations and serum lipids are relevant to racial differences in rates of cardiovascular disease. (C) 2014 Elsevier Ltd. All rights reserved.