Testosterone and dihydrotestosterone differentially improve cognition in aged female mice
Testosterone and dihydrotestosterone differentially improve cognition in aged female mice
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DOI：
10.1101/lm.1428209
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发表时间：
2009-08-01
影响因子：
2
通讯作者：
Raber, Jacob
中科院分区：
文献类型：
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作者：
Benice, Ted S.;Raber, Jacob
与年龄匹配的雄性小鼠相比，雌性小鼠经历了更严重的年龄相关的认知衰退（ACD）。由于雄激素在老年雌性小鼠中的含量低于老年雄性小鼠，因此雄激素补充剂可能会增强老年雌性小鼠的认知能力。为了验证这一点，我们评估了22至24个月大的性腺完整的雌性小鼠在各种任务中的行为表现，这些小鼠用含有睾酮（T）或双氢睾酮（DHT）的硅橡胶胶囊或空胶囊（安慰剂）治疗6周。与安慰剂处理的小鼠相比，睾酮处理的小鼠在水迷宫中的空间记忆保持能力得到增强，而DHT处理的小鼠则没有。相比之下，双氢睾酮治疗改善被动回避（PA）的保留，而T治疗只是这样做的边缘。这些数据支持雄激素补充剂在老年雌性小鼠中改善认知表现的差异取决于激素治疗和认知任务的类型。
Compared with age-matched male mice, female mice experience a more severe age-related cognitive decline (ACD). Since androgens are less abundant in aged female mice compared with aged male mice, androgen supplementation may enhance cognition in aged female mice. To test this, we assessed behavioral performance on a variety of tasks in 22-to 24-mo-old gonadally intact female mice treated for 6 wk with silastic capsules containing either testosterone (T) or dihydrotestosterone (DHT) or empty capsules (placebo). Compared with placebo-treated mice, spatial memory retention in the water maze was enhanced by testosterone treatment, but not DHT treatment. In contrast, DHT treatment improved passive avoidance (PA) retention, while T treatment only did so marginally. These data support that androgen supplementation in old female mice improves cognitive performance differentially depending upon the type of hormone treatment and cognitive task.