COMPARISON OF CONJUNCTIVAL AND CORNEAL SURFACE-AREAS IN RABBIT AND HUMAN
COMPARISON OF CONJUNCTIVAL AND CORNEAL SURFACE-AREAS IN RABBIT AND HUMAN
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DOI：
10.3109/02713688809031801
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发表时间：
1988-05-01
影响因子：
2
通讯作者：
EDELHAUSER, HF
中科院分区：
文献类型：
--
作者：
WATSKY, MA;JABLONSKI, MM;EDELHAUSER, HF
这项比较研究表明，人类结膜与角膜的表面积比是兔子的两倍。这种巨大的迄今未被认识到的物种间差异可能会影响使用兔模型获得的药物药代动力学数据的适用性，在局部药物开发和未来兔与人之间比较药物渗透研究中应该考虑到这一点。
This comparative study shows the surface area ratio of conjunctiva to cornea to be two times larger in humans than in rabbits. This large heretofore unrecognized interspecies difference may affect the applicability of drug pharmacokinetic data obtained using rabbit models and should be taken into consideration in topical drug development and future comparative drug penetration studies between rabbit and man.