Abnormalities of left colonic motility in ambulant nonconstipated patients with irritable bowel syndrome
Abnormalities of left colonic motility in ambulant nonconstipated patients with irritable bowel syndrome
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DOI：
10.1023/a:1021734414976
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发表时间：
2003-01-01
影响因子：
3.1
通讯作者：
Smout, AJPM
中科院分区：
文献类型：
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作者：
Clemens, CHM;Samsom, M;Smout, AJPM
我们的目的是评估左结肠动力模式记录的生理条件下，在24小时内完全走动非便秘IBS患者与健康对照组相比。在11名非便秘型IBS患者和10名年龄和性别匹配的健康志愿者中进行了42小时的左结肠测压。第1天，放置6通道、10 cm间隔的固态导管。在第2天的24小时研究期间，计算降结肠和乙状结肠分段压力波的频率、振幅和运动指数（MI）。高振幅传播性收缩（HAPC）进行了视觉识别，并计算其特性。在IBS患者中，与降结肠相比，在乙状结肠中观察到更高频率的分段压力波（P = 0.006）。相比之下，在对照组中没有观察到区域差异。觉醒（P = 0.048）以及吃饭（P = 0.024）与IBS患者降结肠收缩频率的增加幅度较小相关。IBS患者HAPC发生率高于对照组（P= 0.035）。肠易激综合征患者的HAPC达到更远的结肠水平，更频繁地出现在集群。IBS患者排便前总是出现HAPCs簇，而对照组则不然。总之，非便秘型IBS患者的左结肠分段压力波和HAPC特征发生改变。
Our objective was to evaluate left colonic motility patterns recorded under physiological conditions during 24 hr in fully ambulant nonconstipated IBS patients compared to healthy controls. A 42-hr manometry of the left colon was performed in 11 nonconstipated IBS patients and 10 age- and sex-matched healthy volunteers. On day 1, a 6-channel, 10-cm interval, solid-state catheter was positioned. Frequency, amplitude, and motility index (MI) of segmenting pressure waves in the descending and sigmoid colon were calculated during the 24-hr study period on day 2. High-amplitude propagated contractions (HAPCs) were identified visually and their characteristics were calculated. In IBS patients a higher frequency of segmenting pressure waves was observed in the sigmoid colon compared to the descending colon (P = 0.006). In contrast, no regional differences were observed in controls. Awakening (P = 0.048) as well as having a meal (P = 0.024) was associated with a smaller increase of contraction frequency in the descending colon of IBS patients compared to controls. HAPCs occurred more frequently in IBS patients than in controls (P= 0.035). HAPCs in IBS patients reached a more distal colonic level and occurred more frequently in clusters. Defecation in IBS patients, but not in controls was always preceded by a cluster of HAPCs. In conclusion, left colonic segmenting pressure waves and HAPC characteristics are altered in nonconstipated IBS patients.