Lactobacillus rhamnosus GR-1 and L. reuteri RC-14 to prevent or cure bacterial vaginosis among women with HIV
Lactobacillus rhamnosus GR-1 and L. reuteri RC-14 to prevent or cure bacterial vaginosis among women with HIV
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DOI：
10.1016/j.ijgo.2010.07.008
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发表时间：
2010-12-01
影响因子：
3.8
通讯作者：
Reid, Gregor
中科院分区：
文献类型：
--
作者：
Hummelen, Ruben;Changalucha, John;Reid, Gregor
目的：评价长期口服鼠李糖乳杆菌GR-1和罗伊氏乳杆菌RC-14是否能预防细菌性阴道病（BV）并提高甲硝唑治愈率。方法：一项随机、双盲、安慰剂对照试验，对65名微生物群异常（纽金特评分4-10分）的hiv感染妇女进行了研究，这些妇女被随机分为每天服用益生菌或安慰剂，持续6个月。BV患者（纽金特评分7-10分）另外给予甲硝唑治疗10天（400毫克，每日两次）。结果：与甲硝唑治疗相比，我们没有发现辅助益生菌治疗能提高女性HIV感染者BV的治愈率。在阴道菌群中等的女性中，益生菌倾向于增加阴道正常菌群的可能性（优势比2.4；P=0.1），并显著增加阴道有益pH值的可能性（优势比3.8；P=0.02）。结论：补充益生菌鼠李糖L GR-1和罗伊氏乳杆菌RC-14不能提高女性HIV感染者BV的治愈率，但可以预防该人群的BV。试验注册：NCT00536848。(C) 2010年国际妇产科联合会。爱思唯尔爱尔兰有限公司出版。版权所有。
Objective: To assess, among women with HIV, whether long-term oral Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 supplementation can prevent bacterial vaginosis (BV) and enhance the cure rate of metronidazole among those with BV. Methods: A randomized, double-blind, placebo-controlled trial conducted among 65 HIV-infected women with an aberrant microbiota (Nugent score 4-10) who were randomized to receive daily probiotics or placebo for 6 months. Those with BV (Nugent score 7-10) additionally received metronidazole for 10 days (400 mg twice daily). Results: We did not find an enhanced cure rate of BV among women with HIV treated with adjuvant probiotics to metronidazole treatment. Among women with an intermediate vaginal flora, probiotics tended to increase the probability of a normal vaginal flora (odds ratio 2.4; P=0.1) and significantly increased the probability of a beneficial vaginal pH (odds ratio 3.8; P=0.02) at follow-up. Conclusion: Supplementation of probiotic L rhamnosus GR-1 and L. reuteri RC-14 did not enhance the cure of BV among women living with HIV, but may prevent the condition among this population. Trial registration: NCT00536848. (C) 2010 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.