Brain Metastasis Cell Lines Panel: A Public Resource of Organotropic Cell Lines.
Brain Metastasis Cell Lines Panel: A Public Resource of Organotropic Cell Lines.
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DOI：
10.1158/0008-5472.can-20-0291
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发表时间：
2020-10-15
期刊：
影响因子：
11.2
通讯作者：
Winkler F
中科院分区：
文献类型：
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作者：
Valiente M;Van Swearingen AED;Anders CK;Bairoch A;Boire A;Bos PD;Cittelly DM;Erez N;Ferraro GB;Fukumura D;Gril B;Herlyn M;Holmen SL;Jain RK;Joyce JA;Lorger M;Massague J;Neman J;Sibson NR;Steeg PS;Thorsen F;Young LS;Varešlija D;Vultur A;Weis-Garcia F;Winkler F
尽管肺癌、乳腺癌和黑色素瘤患者的病例数量不断增加，但癌症向脑部扩散仍然是一个未得到满足的临床需求。虽然脑转移瘤的研究在过去被认为是一个次要的方面，由于其不可治疗的性质和不变的致命性，现在有限的，但令人鼓舞的例子质疑这一说法，使其更有吸引力的基础和临床研究人员。其自身生物学特性（即特定微环境）和特定治疗要求（即血脑屏障、血肿瘤屏障的存在、与原发性肿瘤的分子差异）的证据被认为是必须使用临床前模型进行功能性开发的关键方面。我们提出了19个实验室的协调努力，以汇编有关脑转移实验模型的全面信息。每个实验室都提供了他们所产生或表征为能够在大脑中形成转移性集落的癌细胞系的详细信息，以及脑转移研究的原则方法。脑转移细胞系组（BrMPanel）代表了该类中的第一个，包括有关细胞系的信息，如何建立对脑的向性以及每个模型的体内行为。所描述的这些和其他方面旨在帮助研究人员选择最合适的细胞系用于脑转移的研究。这项工作的主要目标是促进对这一未满足的临床需求的研究，通过协作环境改进模型，并促进这些宝贵资源的信息交流。
Spread of cancer to the brain remains an unmet clinical need in spite of the increasing number of cases among patients with lung, breast cancer and melanoma most notably. Although research on brain metastasis was considered a minor aspect in the past due to its untreatable nature and invariable lethality, nowadays limited but encouraging examples have questioned this statement making it more attractive for basic and clinical researchers. Evidences of its own biological identity (i.e. specific microenvironment) and particular therapeutic requirements (i.e. presence of blood-brain barrier, blood-tumor barrier, molecular differences with the primary tumor) are thought to be critical aspects that must be functionally exploited using preclinical models. We present the coordinated effort of 19 laboratories to compile comprehensive information related to brain metastasis experimental models. Each lab has provided details on the cancer cell lines they have generated or characterized as being capable of forming metastatic colonies in the brain, as well as principle methodologies of brain metastasis research. The Brain Metastasis Cell Lines Panel (BrMPanel) represents the first of its class and includes information about the cell line, how tropism to the brain was established and the behavior of each model in vivo. These and other aspects described are intended to assist investigators in choosing the most suitable cell line for research on brain metastasis. The main goal of this effort is to facilitate research on this unmet clinical need, to improve models through a collaborative environment, and to promote the exchange of information on these valuable resources.