The influence of lipids on voltage-gated ion channels.
The influence of lipids on voltage-gated ion channels.
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DOI：
10.1016/j.sbi.2012.03.009
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发表时间：
2012-08
影响因子：
6.8
通讯作者：
Gonen T
中科院分区：
文献类型：
--
作者：
Jiang QX;Gonen T
Voltage-gated ion channels are responsible for transmitting electrochemical signals in both excitable and non-excitable cells. Structural studies of voltage-gated potassium and sodium channels by X-ray crystallography have revealed atomic details on their voltage-sensor domains and pore domains, and were put in context of disparate mechanistic views on the voltage-driven conformational changes in these proteins. Functional investigation of voltage-gated channels in membranes, however, showcased a mechanism of lipid-dependent gating for voltage-gated channels, suggesting that the lipids play an indispensible and critical role in the proper gating of many of these channels. Structure determination of membrane-embedded voltage-gated ion channels appears to be the next frontier in fully addressing the mechanism by which the voltage sensor domains control channel opening. Currently electron crystallography is the only structural biology method in which a membrane protein of interest is crystallized within a complete lipid-bilayer mimicking the native environment of a biological membrane. At a sufficiently high resolution, an electron crystallographic structure could reveal lipids, the channel and their mutual interactions at the atomic level. Electron crystallography is therefore a promising avenue toward understanding how lipids modulate channel activation through close association with the voltage sensor domains.
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影响因子：
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作者：
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通讯作者：
MacKinnon, R
DOI：
10.1073/pnas.0711533105
发表时间：
2008-02-05
影响因子：
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作者：
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