The Minority and Rural Coronavirus Insights Study: Design and Baseline Characteristics of a Minority Cohort.
The Minority and Rural Coronavirus Insights Study: Design and Baseline Characteristics of a Minority Cohort.
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少数民族和农村冠状病毒洞察研究：少数民族群体的设计和基线特征。
DOI：
10.1089/pop.2023.0168
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发表时间：
2023
影响因子：
2.5
通讯作者：
Ba
中科院分区：
文献类型：
--
作者：
Coudray,MakellaS;Hansel,Shantoy;Mata-McMurry,LinaV;Il'yasova,Dora;Lee,LaTasha;Chalasani,Nishanth;Edwards,Christina;Puckrein,Gary;Meyer3rd,WilliamA;Landry,LatriceG;Wiltz,Gary;Sampson,Marian;BrandtDee,Todd;Gregerson,Paul;Ba
少数民族和农村冠状病毒洞察研究（MRCIS）是一项正在进行的前瞻性队列研究，旨在研究医疗服务不足人群中与SARS-CoV-2感染相关的健康差异。本报告描述了建立MRCIS队列的程序，并检查了参与者入组时与SARS-CoV-2感染状态的分子和血清学评估相关的因素。参与者是在2020年11月至2021年4月期间从5个地理上分散的联邦合格健康中心招募的。在基线时，参与者完成了详细的人口统计学调查，并收集了生物样本进行测试。根据分子和血清学检测结果确定SARS-CoV-2感染状态。进行卡方和logistic回归分析，以检查社会人口因素、COVID-19安全措施、现有合并症和SARS-CoV-2感染状态之间的关联。最终队列包括3238名参与者。参与者的平均年龄为50.2 ± 15.8岁。大多数参与者被认为是女性（60.0%），异性恋或异性恋（93.0%），白色（47.6%）和西班牙裔或拉丁裔（49.1%）。大约26.1%的参与者至少有一次SARS-CoV-2检测结果呈阳性。主要效应模型包括年龄、性别和人种/种族。与≥65岁的成年人相比，所有其他年龄组的参与者SARS-CoV-2检测结果呈阳性的几率增加了2.2倍。此外，与非西班牙裔白人相比，少数种族/民族的SARS-CoV-2感染状态呈阳性的几率增加了102倍。建立了一个独特的队列，传统上医疗服务不足的少数民族人口。在基线SARS-CoV-2感染状态中发现了显著的种族和民族差异。
The Minority and Rural Coronavirus Insights Study (MRCIS) is an ongoing prospective cohort study examining health disparities associated with SARS-CoV-2 infection among medically underserved populations. This report describes procedures implemented to establish the MRCIS cohort and examines the factors associated with the molecular and serological assessment of SARS-CoV-2 infection status at participant enrollment. Participants were recruited from 5 geographically dispersed federally qualified health centers between November 2020 and April 2021. At baseline, participants completed a detailed demographic survey and biological samples were collected for testing. SARS-CoV-2 infection status was determined based on the combined molecular and serological test results. Chi-squared and logistic regression analyses were conducted to examine associations between sociodemographic factors, COVID-19 safety measures, existing comorbidities, and SARS-CoV-2 infection status. The final cohort included 3238 participants. The mean age of participants was 50.2 ± 15.8 years. Most participants identified as female (60.0%), heterosexual or straight (93.0%), White (47.6%), and Hispanic or Latino (49.1%). Approximately 26.1% of participants had at least one positive SARS-CoV-2 test result. The main effect model included age, sex, and race/ethnicity. Compared with adults ≥65 years, participants in all other age groups had ∼2 times increased odds of a positive SARS-CoV-2 test result. In addition, racial/ethnic minorities had ∼2 times increased odds of a positive SARS-CoV-2 infection status compared with non-Hispanic Whites. A unique cohort of a traditionally medically underserved minority population was established. Significant racial and ethnic disparities in SARS-CoV-2 infection status at baseline were discovered.