Error blindness and motivational significance: Shifts in networks centering on anterior insula co-vary with error awareness and pupil dilation
Error blindness and motivational significance: Shifts in networks centering on anterior insula co-vary with error awareness and pupil dilation
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DOI：
10.1016/j.bbr.2017.10.030
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发表时间：
2018-12-14
影响因子：
2.7
通讯作者：
Ridderinkhof, K. Richard
中科院分区：
文献类型：
--
作者：
Harsay, Helga A.;Cohen, Michael X.;Ridderinkhof, K. Richard
这项调查旨在进一步了解大脑机制的基础上意识到一个人的错误行为。虽然所有的错误都在喙侧扣带区被记录下来，但只有当前扣带皮层被激活时，错误才能进入意识。意识到但不是不知道的错误会引起自主神经系统的反应。我们的目的是调查这一假设，激活在错误意识过程中的大脑皮层与自主觉醒和跨区域的相互作用与大脑的其他区域。为了研究前额叶在错误意识中的作用，我们评估了其与其他大脑区域的功能连接，沿着自主神经系统的反应，这些参与者在执行复杂且容易出错的任务时同时进行瞳孔直径和功能磁共振成像测量。错误盲与未能充分参与自主反应有关。在有意识的错误增加瞳孔直径沿着与增加任务相关的激活内，和增加前额叶和任务相关的网络之间的连接表明增加的能力，行动控制信息传递。在意识错误过程中瞳孔直径的增加还与默认模式网络的激活减少有关，沿着与默认模式系统区域的岛屿连接减少，这可能反映了与任务无关的信息处理减少。这种转变机制可能与更好地理解大脑和自主神经系统如何相互作用以在认知挑战期间实现有效的适应行为有关
This investigation aims to further our understanding of the brain mechanisms underlying the awareness of one's erroneous actions. While all errors are registered as such in the rostral cingulate zone, errors enter awareness only when the anterior insula cortex is activated. Aware but not unaware errors elicit autonomic nervous system reactivity. Our aim is to investigate the hypothesis that activation in the insula during error awareness is related to autonomic arousal and to inter-regional interactions with other areas of the brain. To examine the role of the anterior insula in error awareness, we assessed its functional connectivity to other brain regions along with autonomic nervous system reactivity in young healthy participants who underwent simultaneous pupil-diameter and functional magnetic resonance imaging measurements while performing a complex and error-prone task. Error blindness was associated with failures to engage sufficient autonomic reactivity. During aware errors increased pupil-diameter along with increased task-related activation within, and increased connectivity between anterior insula and task-related networks suggested an increased capacity for action-control information transfer. Increased pupil-diameter during aware errors was furthermore associated with decreased activation of the default-mode network along with decreased insular connectivity with regions of the default mode system, possibly reflecting decreased task-irrelevant information processing. This shifting mechanism may be relevant to a better understanding of how the brain and the autonomic nervous system interact to enable efficient adaptive behavior during cognitive challenge