Synthesis of novel benzocoumarin derivatives as lipid lowering agents
Synthesis of novel benzocoumarin derivatives as lipid lowering agents
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DOI：
10.1016/j.bmcl.2010.03.103
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发表时间：
2010-05-15
影响因子：
2.7
通讯作者：
Khanna, A. K.
中科院分区：
文献类型：
--
作者：
Sashidhara, Koneni V.;Rosaiah, Jammikuntla N.;Khanna, A. K.
合成了一系列新型苯并香豆素衍生物，并对其体内抗血脂和体外抗氧化活性进行了评价。初步筛选表明化合物4具有显著的降脂和抗氧化活性，是潜在的先导化合物。该研究表明，基于苯并香豆素的药效团是一种生物学上重要的支架，这种尝试可能会导致抗血脂异常的新铅的鉴定。(C)2010爱思唯尔有限公司版权所有。
A series of novel benzocoumarin derivatives were synthesized and evaluated for their in vivo anti-dyslipidemic and in vitro antioxidant activities. Preliminary screening indicates compound 4 as potential lead with significant lipid lowering and antioxidant activities. The study revealed that such attempts on benzocoumarin-based pharmacophores which is a biologically important scaffold might result in identification of new lead for anti-dyslipidemia. (C) 2010 Elsevier Ltd. All rights reserved.