Spanlastics-A novel nanovesicular carrier system for ocular delivery
Spanlastics-A novel nanovesicular carrier system for ocular delivery
复制标题
DOI：
10.1016/j.ijpharm.2011.04.027
复制
发表时间：
2011-07-15
影响因子：
5.8
通讯作者：
Kaur, Indu Pal
中科院分区：
文献类型：
--
作者：
Kakkar, Shilpa;Kaur, Indu Pal
这项工作描述了一种新型的、基于表面活性剂的弹性泡囊药物载体系统(Spanlastics)的有用性，用于将局部应用的药物(S)靶向于眼后段。该体系由Span 60和边缘激活剂(吐温80)组成。酮康唑是一种大分子量亲脂药物，其极限溶解度为531.44.0 4 mg/ml，预计难以通过角膜，因此没有眼用制剂。已开发的伸展弹性体具有纳米尺寸和弹性性质。它们的角膜渗透率提高了2倍(p
The work describes usefulness of a novel, surfactants based elastic vesicular drug carrier system (spanlastics), for targeting topically applied drug(s) to the posterior segment of the eye. The system constituted span 60 and a edge activator (tween 80).Ketoconazole, a lipophilic drug with a large molecular weight of 531.44 Da and a limiting solubility of 0.04 mg/ml is expected to show a poor transport across the cornea; hence no ocular formulations are available. Developed spanlastics were of nanosize and elastic in nature. They showed 2 times better corneal permeation (p