THE FATAL ENTERIC CHOLERA INFECTION IN THE GUINEA PIG, ACHIEVED BY INHIBITION OF NORMAL ENTERIC FLORA
THE FATAL ENTERIC CHOLERA INFECTION IN THE GUINEA PIG, ACHIEVED BY INHIBITION OF NORMAL ENTERIC FLORA
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DOI：
10.1093/infdis/97.1.57
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发表时间：
1955-01-01
影响因子：
6.4
通讯作者：
FRETER, R
中科院分区：
文献类型：
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作者：
FRETER, R
用链霉素抑制豚鼠肠道正常植物群后，豚鼠可定期感染耐药的霍乱弧菌。实验感染是致命的，仅限于肠道。高粘蛋白酶活性的液体在感染动物的肠道中积累。用煮沸的弧菌或含粘蛋白酶的培养液免疫豚鼠可保护豚鼠免受实验感染。大剂量的内毒素以热灭活弧菌或水溶性毒素制剂的形式口服给药时对豚鼠没有影响。
Guinea pigs could be regularly infected with a drug resistant strain of Vibrio cholerae after their normal enteric flora had been inhibited with streptomycin. The experimental infection was fatal and limited to the bowel. Accumulation of fluids with high mucinase activity occurred in the intestines of infected animals. Immunization with boiled vibrios or with culture filtrates containing mucinase protected guinea pigs against the experimental infection. Large doses of endotoxin in the form of heat killed vibrios or of water soluble toxin preparations did not affect guinea pigs when given orally.