Correlation of tumor marker expression with nodal disease burden in metastatic head and neck cancer.
Correlation of tumor marker expression with nodal disease burden in metastatic head and neck cancer.
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DOI：
10.1177/0194599813486876
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发表时间：
2013-08
期刊：
影响因子：
--
通讯作者：
Ferris RL
中科院分区：
文献类型：
--
作者：
Trivedi S;Mattos J;Gooding W;Godfrey TE;Ferris RL
目的探讨寻常型天疱疮抗原(PVA)、甲状旁腺激素相关肽(PTHrP)、肿瘤相关钙信号转导蛋白1(TACSTD1)3个标志物基因表达水平与头颈部鳞状细胞癌(HNSCC)淋巴结转移率的关系。此外，我们还调查了这三种标记物的表达水平是否与HNSCC患者的临床预后有关。对以前采集的患者样本进行回顾分析。匹兹堡大学。应用实时定量聚合酶链式反应检测92例HNSCC患者的448个淋巴结中PVA、PTHrP和TACSTD1基因的表达。转移的确认由组织学检查确定。分析这些标志物的表达水平与肿瘤百分率的关系。所有3种标志物均独立研究，并与转移淋巴结的肿瘤百分率相关。PVA相关性最强，PTHrP次之，TACSTD1次之。PVA水平与临床结局，特别是癌症引起的死亡时间有相关趋势，但这与肿瘤分期相混淆。3种肿瘤基因标志物均与转移淋巴结中肿瘤细胞百分率相关。PVA相关性最强。PVA可能会增加病理分期以外的预后价值，但这需要对更大的队列进行分析。对转移结节内肿瘤体积的前瞻性研究应确定分子标志物检测的下限阈值。
To investigate the correlation between the percentage of metastatic tumor present in lymph nodes resected from patients with squamous cell carcinoma of the head and neck (HNSCC) and level of expression of 3 marker genes: pemphigus vulgaris antigen (PVA), parathyroid hormone–related peptide (PTHrP), and tumor-associated calcium signal transducer 1 (TACSTD1). In addition, we investigated whether the level of expression of these 3 markers was associated with clinical outcomes for patients with HNSCC. Retrospective analysis of previously harvested patient samples. The University of Pittsburgh. A total of 448 lymph nodes from 92 patients with HNSCC were evaluated for expression of the gene markers PVA, PTHrP, and TACSTD1 using real-time polymerase chain reaction. Confirmation of metastasis was determined by histologic examination. The expression level of these markers versus tumor percentage was analyzed. All 3 markers were studied independently and were associated with tumor percentage in metastatic lymph nodes. PVA had the strongest correlation, followed by PTHrP and then TACSTD1. PVA levels had a trend toward association with clinical outcome, specifically time to death caused by cancer, but this was confounded by tumor stage. All 3 tumor gene markers were associated with percentage of tumor cells in metastatic lymph nodes. PVA had the strongest correlation. PVA may add prognostic utility beyond pathologic staging, but this requires analysis of a larger cohort. Prospective studies of tumor volume in metastatic nodes should determine a lower limit threshold of molecular marker detection.
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DOI：
10.1002/hed.20482
发表时间：
2007-01-01
影响因子：
2.9
作者：
Capote, Ana;Escorial, Veronica;Naval, Luis
通讯作者：
Naval, Luis
DOI：
10.1002/hed.20254
发表时间：
2005-09-01
影响因子：
2.9
作者：
Le Tourneau, C;Velten, M;Borel, C
通讯作者：
Borel, C
影响因子：
9.6
作者：
Sato, F;Shimada, Y;Imamura, M
通讯作者：
Imamura, M
影响因子：
2.6
作者：
Rhee, D;Wenig, BM;Smith, RV
通讯作者：
Smith, RV
影响因子：
2.1
作者：
Seethala, Raja R.
通讯作者：
Seethala, Raja R.