NASAL AND BRONCHIAL PROVOCATION CHALLENGES WITH BAYBERRY (MYRICA-CERIFERA) POLLEN EXTRACT
NASAL AND BRONCHIAL PROVOCATION CHALLENGES WITH BAYBERRY (MYRICA-CERIFERA) POLLEN EXTRACT
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DOI：
10.1016/s0091-6749(05)80008-9
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发表时间：
1992-09-01
影响因子：
14.2
通讯作者：
LOCKEY, RF
中科院分区：
文献类型：
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作者：
JACINTO, CM;NELSON, RP;LOCKEY, RF
南部杨梅，分布在整个美国东南部，是第五个最常见的风传树木花粉在坦帕，弗拉的来源。在坦帕湾地区，400名连续受试者中有15%的人对杨梅花粉提取物的皮肤试验呈阳性。杨梅花粉提取物是商业获得的，并用于对45名受试者进行25次鼻和22次支气管激发。13名过敏性鼻炎和杨梅花粉提取物皮肤试验阳性的研究受试者中有12名（92%）和12名皮肤试验阴性的对照受试者中有2名（17%）鼻激发试验阳性（p = 0.0001）。7例（57%）外源性哮喘且杨梅花粉提取物皮肤试验阳性的研究受试者中有4例（0%）和15例（0%）皮肤试验阴性的对照受试者中无一例（p = 0.001）支气管激发试验阳性。采用平板放射免疫法测定了30名接受31次激发的受试者的血清中杨梅花粉提取物特异性IgE。特异性IgE抗体存在于8/13例（62%）阳性激发受试者的血清中，而不存在于15/18例（83%）阴性激发受试者的血清中（p = 0.01）。杨梅花粉提取物皮内皮试比平板放射免疫法更能预测激发试验结果（阳性预测值为80%，95% CI 62%至98%;对73%，95% CI 47%至99%）。杨梅花粉提取物是过敏性的，南方杨梅树符合美国人定义的产生空气过敏原的植物的标准。
Southern bayberry, distributed throughout the southeastern United States, is the source of the fifth most common windborne tree pollen in Tampa, Fla. Fifteen percent of 400 consecutive subjects evaluated for allergic respiratory symptoms in the Tampa Bay area had positive skin tests to bayberry pollen extract. Bayberry pollen extract was obtained commercially and used to perform 25 nasal and 22 bronchial challenges on 45 subjects. Twelve of 13 (92%) study subjects with allergic rhinitis and positive skin tests to bayberry pollen extract and two of 12 (17%) control subjects with negative skin tests had positive nasal challenges (p = 0.0001). Four of seven (57%) study subjects with extrinsic asthma and positive skin tests to bayberry pollen extract and none of the 15 (0%) control subjects with negative skin tests had positive bronchial challenges (p = 0.001). Sera from 30 subjects who underwent 31 challenges were assayed for bayberry pollen extract-specific IgE by plate radioimmunoassay. Specific IgE antibodies were present in the sera of 8 of 13 (62%) subjects with positive challenges and absent in 15 of 18 (83%) subjects with negative challenges (p = 0.01). Intradermal skin tests with bayberry pollen extract were more predictive of provocation challenge results than plate radioimmunoassay (positive predictive value of 80%, 95% CI 62% to 98%; versus 73%, 95% CI 47% to 99%). Bayberry pollen extract is allergenic, and the Southern bayberry tree fulfills Thommen's criteria defining aeroallergen-producing plants.