The role of serotonin in the "dumping syndrome".
The role of serotonin in the "dumping syndrome".
复制标题
血清素在“倾倒综合症”中的作用。
作者：
G. Peskin;L. Miller
自从 Denechau、1Hertz、2 和 Mix3 最初描述“倾倒综合症”以来，大量的临床和实验工作致力于研究这组奇怪的症状和体征的定义和病因。个体反应在很大范围内变化，但一般可分为肠道和血管舒缩成分。该综合征的“肠道”部分可能包括蠕动亢进、腹胀、上腹不适和饱腹感、轻度痉挛、肠鸣、恶心，偶尔还会出现呕吐和腹泻。血管舒缩成分实际上将“倾倒”与其他胃切除术后综合征区分开来，可能表现为虚弱、头晕、苍白、心动过速、出汗、心悸和想要躺下。在更严重的情况下，该综合征可能会使患者完全丧失能力。在过去的二十年里，关于病因学的理论的接受度有起有落。例如，据称该综合征是由于
Since the original description of the "dumping syndrome" by Denechau,1Hertz,2and Mix,3a great deal of clinical and experimental work has been devoted to the definition and etiology of this curious group of symptoms and signs. Individual reactions vary within broad limits, but, in general, may be divided into intestinal and vasomotor components. The "intestinal" portion of the syndrome may include hyperperistalsis, bloating, epigastric discomfort and fullness, mild cramps, borborygmi, nausea, and, occasionally, vomiting and diarrhea. The vasomotor component actually distinguishes "dumping" from other postgastrectomy syndromes and may be manifested by weakness, dizziness, pallor, tachycardia, sweating, palpitation, and a desire to lie down. In its more severe forms, the syndrome may be totally disabling for the patient. Theories as to etiology have waxed and waned in acceptance in the past 2 decades. For example, the syndrome has been purported to be due to a reduction in