Tumour cell damage and leucocyte infiltration after laser immunotherapy treatment
Tumour cell damage and leucocyte infiltration after laser immunotherapy treatment
复制标题
DOI：
10.1007/s101030050046
复制
发表时间：
2000-01-01
影响因子：
2.1
通讯作者：
Nordquist, RE
中科院分区：
文献类型：
--
作者：
Chen, WR;Liu, H;Nordquist, RE
应用激光光敏剂后的免疫反应在癌症治疗中可能是至关重要的，因为没有它，就不可能有系统的、长期的肿瘤控制。激光免疫疗法是一种治疗转移性肿瘤的新方法，它使用近红外激光、激光吸收染料吲哚青绿和免疫佐剂糖化壳聚糖。这种方法在治疗大鼠乳腺转移瘤中显示了诱导的抗肿瘤免疫反应。用光学显微镜和电子显微镜研究了这种新方法对肿瘤细胞结构和浸润性免疫细胞的影响。肿瘤样本在治疗前和治疗后立即进行了急性效应检查，主要表现为光热效应。治疗2周后，存活的肿瘤细胞周围可见明显的淋巴细胞和浆细胞浸润。这些形态学研究结果表明，细胞免疫反应和体液免疫反应都可能是肿瘤根除和诱导肿瘤长期耐药的原因。
Immune response after laser-photosensitiser application could be crucial in treatment of cancers, because without it there could be no systemic, long-term tumour control. Laser immunotherapy, a novel method for treatment of metastatic tumours, uses a near-infrared laser, a laser-absorbing dye indocyanine green, and an immunoadjuvant glycated chitosan. This modality has shown an induced antitumour immune response in treatment of rat mammary metastatic tumours. The influence of this new method on the cellular structure of the tumours and on the infiltrating immune cells was studied using optical and electron microscopes. The tumour samples were examined before and immediately after the treatment for acute effects, which appeared mainly photothermal. Two weeks after treatment, significant infiltrating lymphocytes and plasma cells were found around the surviving tumour cells. These morphological findings suggest that both cell-mediated and humoral immune responses could be responsible for the observed tumour eradication and induced long-term tumour resistance.