THE EPIDEMIOLOGY AND POPULATION BIOLOGY OF NECATOR-AMERICANUS INFECTION IN A RURAL-COMMUNITY IN ZIMBABWE
THE EPIDEMIOLOGY AND POPULATION BIOLOGY OF NECATOR-AMERICANUS INFECTION IN A RURAL-COMMUNITY IN ZIMBABWE
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DOI：
10.1016/0035-9203(92)90448-l
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发表时间：
1992-01-01
影响因子：
2.2
通讯作者：
MEDLEY, GF
中科院分区：
文献类型：
--
作者：
BRADLEY, M;CHANDIWANA, SK;MEDLEY, GF
介绍了津巴布韦一个农村社区钩虫感染流行病学研究的基线数据。使用驱虫驱逐技术的年龄分层样本的社区的感染状况进行了评估。美洲钩虫是唯一发现的蠕虫寄生虫。年龄患病率和强度曲线逐渐上升至成人患病率约80%，成人平均负担为每宿主7.7条蠕虫。总体平均负荷为每宿主4.8条蠕虫。N. americanus过度分散，可以用负二项分布很好地描述，聚集参数k值为0.346。男性和老年宿主对k的单独估计值较低。这种分布模式很难与任何简单的年龄依赖性获得有效免疫应答的过程相一致。一个显着的负相关关系，每头生殖力和蠕虫负担之间的记录，提供证据的密度依赖性调节雌虫生殖力。发现基本生殖率（R0等于2）与其他地理区域的估计相似。
Baseline data from an epidemiological study of hookworm infection in a rural community in Zimbabwe are presented. The infection status of an age-stratified sample of the community was assessed using anthelmintic expulsion techniques. Necator americanus was the only helminth parasite found to be present. The age-prevalence and intensity profiles rose asymptotically to an adult prevalence of about 80% and adult mean burden of 7.7 worms per host. The overall mean burden was 4.8 worms per host. The frequency distribution of N. americanus was overdispersed and well described by the negative binomial distribution with a value for the aggregation parameter, k, of 0.346. Separate estimates of k were lower in males and older hosts. The distribution patterns were difficult to reconcile with any simple process of age-dependent acquisition of an effective immune response. A significant negative correlation was recorded between per caput fecundity and worm burden, providing evidence for a density-dependent regulation of female worm fecundity. The basic reproductive rate (R0 congruent-to 2) was found to be similar to estimates from other geographical areas.