HEPATIC GLUCONEOGENESIS AND MITOCHONDRIAL-FUNCTION DURING HIBERNATION
HEPATIC GLUCONEOGENESIS AND MITOCHONDRIAL-FUNCTION DURING HIBERNATION
复制标题
DOI：
10.1016/0305-0491(88)90107-1
复制
发表时间：
1988-01-01
影响因子：
2.2
通讯作者：
APRILLE, JR
中科院分区：
文献类型：
--
作者：
GEHNRICH, SC;APRILLE, JR
1. The aim of these studies was to investigate a mitochondrial basis for changes in gluconeogenesis during hibernation. 2. State 3 respiration rates in liver mitochondria from hibernating ground squirrels were reduced by 62-66%. The limiting reaction apepared to be electron transport, particularly in respiratory complex III. 3. The mitochondrial ATP + ADP + AMP content was reduced by 29% during hibernation; cellular adenine nucleotide content was unchanged. 4. Pyruvate carboxylation in intact mitochondria was decreased 75% during hibernation, although total pyruvate carboxylase activity was not lower. 5. Rats of gluconeogenesis in intact hepatocytes isolated from hibernators were lower than in cells from non-hibernators.
