Combination chemotherapy for advanced Hodgkin's disease in relapse following extensive radiotherapy
Combination chemotherapy for advanced Hodgkin's disease in relapse following extensive radiotherapy
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联合化疗治疗广泛放疗后复发的晚期霍奇金病
DOI：
10.1002/cpt1972135part1750
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发表时间：
1972
影响因子：
6.7
通讯作者：
V. Devita
中科院分区：
文献类型：
--
作者：
G. Canellos;R. Young;V. Devita
21 名霍奇金病患者在广泛放疗后复发，接受了联合化疗方案 (MOPP) 治疗，其中包括氮芥、长春新碱、泼尼松和丙卡巴肼，为期 6 个月的周期。十六名患者（76%）获得完全缓解。在一组患有广泛疾病但既往未接受过放疗的患者中，总体缓解率和骨髓抑制程度相似。放疗结束和化疗开始之间的间隔与随后药物毒性的程度不相关。具有治愈目的的强化放疗后霍奇金病复发的患者并不排除随后对联合化疗的良好反应和延长的无病间隔。
Twenty one patients with Hodgkin's disease who were in relapse following extensive radiation therapy were treated with a combination chemotherapy program (MOPP), which included nitrogen mustard, vincristine, prednisone, and procarbazine for 6 monthly cycles. Sixteen patients (76 per cent) achieved complete remission. In a comparable group of patients with extensive disease but no previous radiotherapy the over‐all remission rate and the degree of myelosuppression were similar. The interval between the end of radiotherapy and the onset of chemotherapy did not correlate with the extent of subsequent drug tOXicity. Relapse of Hodgkin's disease in the patients following intensive radiotherapy with curative intent does not preclude a subsequent excellent response to combination chemotherapy and a prolonged disease‐free interval.