Shiga toxin pathogenesis: kidney complications and renal failure.

Shiga toxin pathogenesis: kidney complications and renal failure.
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DOI:
10.1007/82_2011_172
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发表时间:
2012
影响因子:
--
通讯作者:
Karpman, Diana
Karpman, Diana
中科院分区:
医学3区
文献类型:
--
作者:
Obrig, Tom G.;Karpman, Diana

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肾脏是尿毒症相关溶血性尿毒综合征(D+HUS)的主要受累器官。D+HUS中肾脏疾病的病理生理学主要是细菌毒力因子如滋贺毒素和脂多糖与肾脏和血液循环中的宿主细胞之间相互作用的结果。本章详细介绍了这些细菌毒素如何导致肾脏疾病和肾衰竭的现有知识。由特定的血液和居民肾细胞类型表达的毒素受体也讨论了这些细胞上的毒素的行动。
The kidneys are the major organs affected in diarrhea-associated hemolytic uremic syndrome (D+HUS). The pathophysiology of renal disease in D+HUS is largely the result of the interaction between bacterial virulence factors such as Shiga toxin and lipopolysaccharide and host cells in the kidney and in the blood circulation. This chapter describes in detail the current knowledge of how these bacterial toxins may lead to kidney disease and renal failure. The toxin receptors expressed by specific blood and resident renal cell types are also discussed as are the actions of the toxins on these cells.
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