Antiviral Activity of Graphene-Silver Nanocomposites against Non-Enveloped and Enveloped Viruses.
Antiviral Activity of Graphene-Silver Nanocomposites against Non-Enveloped and Enveloped Viruses.
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DOI：
10.3390/ijerph13040430
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发表时间：
2016-04-19
影响因子：
--
通讯作者：
Chang PL
中科院分区：
文献类型：
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作者：
Chen YN;Hsueh YH;Hsieh CT;Tzou DY;Chang PL
新型抗病毒材料的发现非常重要，因为许多传染病都是由病毒引起的。银纳米粒子具有很强的抗病毒活性，石墨烯具有大的表面积、高的载流子迁移率和生物相容性，是一种潜在的抗菌材料。尚未报道纳米材料对无包膜病毒的抗病毒活性研究。为了研究氧化石墨烯（GO）片和具有银颗粒的GO片（GO-Ag）对包膜和非包膜病毒的抗病毒活性，选择具有包膜的猫冠状病毒（FCoV）和不具有包膜的传染性法氏囊病病毒（IBDV）。通过透射电镜、扫描电镜和X射线衍射对GO和GO-Ag的形貌和尺寸进行了表征。采用病毒抑制试验检测GO和GO-Ag的抗病毒活性。Go-Ag对FCoV和IBDV感染的抑制率分别为25%和23%，而GO对FCoV感染的抑制率仅为16%，但对IBDV感染无抗病毒活性。GO和GO-Ag可以考虑进一步应用于个人防护设备，以减少病毒的传播。
The discovery of novel antiviral materials is important because many infectious diseases are caused by viruses. Silver nanoparticles have demonstrated strong antiviral activity, and graphene is a potential antimicrobial material due to its large surface area, high carrier mobility, and biocompatibility. No studies on the antiviral activity of nanomaterials on non-enveloped viruses have been reported. To investigate the antiviral activity of graphene oxide (GO) sheets and GO sheets with silver particles (GO-Ag) against enveloped and non-enveloped viruses, feline coronavirus (FCoV) with an envelope and infectious bursal disease virus (IBDV) without an envelope were chosen. The morphology and sizes of GO and GO-Ag were characterized by transmission, scanning electron microscopy, and X-ray diffraction. A virus inhibition assay was used to identify the antiviral activity of GO and GO-Ag. Go-Ag inhibited 25% of infection by FCoV and 23% by IBDV, whereas GO only inhibited 16% of infection by FCoV but showed no antiviral activity against the infection by IBDV. Further application of GO and GO-Ag can be considered for personal protection equipment to decrease the transmission of viruses.