Lymphatic metastasis in the absence of functional intratumor lymphatics
Lymphatic metastasis in the absence of functional intratumor lymphatics
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DOI：
10.1126/science.1071420
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发表时间：
2002-06-07
期刊：
影响因子：
56.9
通讯作者：
Jain, RK
中科院分区：
文献类型：
--
作者：
Padera, TP;Kadambi, A;Jain, RK
淋巴转移增加了实体瘤的死亡率。转移的癌细胞是否通过肿瘤内淋巴管到达淋巴结尚不清楚。在这里，我们研究了与表达血管内皮生长因子- c （VEGF-C）正常或升高水平的小鼠肿瘤相关的功能性淋巴管，VEGF-C是一种刺激淋巴管生成的分子。尽管VEGF-C过表达增加了肿瘤边缘的淋巴表面积和淋巴转移，但通过四项独立的功能检测和免疫组织化学染色评估，这些肿瘤没有功能淋巴。这些发现表明，仅肿瘤边缘的功能淋巴就足以进行淋巴转移，并且应该有针对性地治疗。
Lymphatic metastasis contributes to mortality from solid tumors. Whether metastasizing cancer cells reach lymph nodes via intratumor lymphatic vessels is unknown. Here, we examine functional lymphatics associated with mouse tumors expressing normal or elevated levels of vascular endothelial growth factor-C (VEGF-C), a molecule that stimulates lymphangiogenesis. Although VEGF-C overexpression increased lymphatic surface area in the tumor margin and lymphatic metastasis, these tumors contained no functional lymphatics, as assessed by four independent functional assays and immunohistochemical staining. These findings suggest that the functional lymphatics in the tumor margin alone are sufficient for lymphatic metastasis and should be targeted therapeutically.