Polarity in Mammalian Epithelial Morphogenesis
Polarity in Mammalian Epithelial Morphogenesis
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DOI：
10.1101/cshperspect.a013789
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发表时间：
2013-02-01
影响因子：
7.2
通讯作者：
Mostov, Keith
中科院分区：
文献类型：
--
作者：
Roignot, Julie;Peng, Xiao;Mostov, Keith
细胞极性是上皮组织结构和功能的基础。上皮极化需要几个基本细胞过程的干预，这些过程在空间和时间上的整合才刚刚开始被阐明。为了了解发育过程中上皮组织构建的控制因素，有必要考虑整个组织背景下的极化过程。为此，三维器官型细胞培养模型的发展为高阶上皮组织结构的建立和维持的机制以及上皮器官发育过程中经常发生的细胞极性的动态重塑带来了新的见解。在这里，我们讨论哺乳动物上皮形态发生的一些重要方面，从细胞极性的建立到上皮组织的生成。
Cell polarity is fundamental for the architecture and function of epithelial tissues. Epithelial polarization requires the intervention of several fundamental cell processes, whose integration in space and time is only starting to be elucidated. To understand what governs the building of epithelial tissues during development, it is essential to consider the polarization process in the context of the whole tissue. To this end, the development of three-dimensional organotypic cell culture models has brought new insights into the mechanisms underlying the establishment and maintenance of higher-order epithelial tissue architecture, and in the dynamic remodeling of cell polarity that often occurs during development of epithelial organs. Here we discuss some important aspects of mammalian epithelial morphogenesis, from the establishment of cell polarity to epithelial tissue generation.