Reflex responses of the isolated, in situ portal vein of the dog.
Reflex responses of the isolated, in situ portal vein of the dog.
复制标题
狗的离体原位门静脉的反射反应。
DOI：
10.1016/0022-4804(75)90139-0
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发表时间：
1975
期刊：
影响因子：
--
通讯作者：
D. Donald
中科院分区：
文献类型：
--
作者：
R. M. Auden;D. Donald
方法数据来自两种性别杂种犬的急性实验;体重范围为10至17 kg（平均值+ SD，12.4+ 1.8 kg）。用静脉内施用的硫喷妥钠（15 mg/kg）诱导麻醉，然后用一定剂量的cY-氯醛糖（80 mg/kg体重）诱导麻醉。每小时给予氯醛糖（5 mg/kg）维持麻醉。每只犬人工吸氧，频率为10-14次/min，吸气峰压为10-14 cm H，O。调整频率和潮气量;必要时，将Pcoz维持在正常范围内。每隔一小时静脉注射碳酸氢钠（1 Q Mequiv），以维持pH值在7.3 - 7.4之间。以3 mg/kg的剂量静脉内给予三乙基碘化没食子胺（Flaxedil）。防止狗在准备过程中的肌肉运动。根据需要给予1 mg/kg的补充剂量。在需要肝素的实验中，静脉内给予2.5 mg/kg的初始剂量，
METHODS The data were obtained from acute experiments in mongrel dogs of both sexes; body weights ranged from 10 to 17 kg (mean+ SD, 12.4+ 1.8 kg). Anesthesia was induced with intravenously administered sodium pentothal (15 mg/kg), followed by a dose of cY-chloralose (80 mg/kg body weight). Anesthesia was maintained with hourly doses of chloralose (5 mg/kg). Each dog was artificially respired with oxygen, at a frequency of 10-14 cycles/min and peak inspiratory pressures of 10-14 cm H, O. Frequency and tidal volume were adjusted; when required, to maintain Pcoz withip normal limits. Sodium bicarbonate was given intravenously at hourly intervals (1Q mequiv) to maintain the pH between 7.3 and 7.4. Gallamine triethiodide (Flaxedil) was given intravenously in a dose of 3 mg/kg to. prevent muscle movement during preparation of the dog. Supplemental doses of 1 mg/kg were given as required. In experiments that required heparin, an initial dose of 2.5 mg/kg was given intravenously,