Osteoblast deletion of exon 3 of the androgen receptor gene results in trabecular bone loss in adult male mice
Osteoblast deletion of exon 3 of the androgen receptor gene results in trabecular bone loss in adult male mice
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DOI：
10.1359/jbmr.061117
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发表时间：
2007-03-01
影响因子：
6.2
通讯作者：
Davey, Rachel A.
中科院分区：
文献类型：
--
作者：
Notini, Amanda J.;McManus, Julie F.;Davey, Rachel A.
在成熟成骨细胞AR缺失的雄性小鼠中研究雄激素对骨的作用机制。这些小鼠的骨小梁体积减少与骨小梁数量减少有关，这表明雄激素可能直接作用于成骨细胞以维持骨小梁。
The mechanism of androgen action on bone was studied in male mice with the AR deleted in mature osteoblasts. These mice had decreased trabecular bone volume associated with a decrease in trabecular number, suggesting that androgens may act directly on osteoblasts to maintain trabecular bone.