A local effect model-based interpolation framework for experimental nanoparticle radiosensitisation data.
A local effect model-based interpolation framework for experimental nanoparticle radiosensitisation data.
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DOI：
10.1186/s12645-016-0025-6
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发表时间：
2017
影响因子：
5.7
通讯作者：
Currell FJ
中科院分区：
文献类型：
--
作者：
Brown JMC;Currell FJ
建立了一个基于局部效应模型（LEM）的框架，该框架能够插值纳米颗粒增强光子照射下克隆细胞存活分数作为纳米颗粒浓度函数的测量结果，并对纳米颗粒（AuNP）掺杂的牛主动脉内皮细胞（BAECs）在浅电压x射线照射下进行了实验基准测试。对于三种不同的表面千伏x射线谱，预测了两种不同的AuNP浓度下BAEC的生存分数反应，并与实验数据进行了比较。分析和讨论了所开发的框架预测细胞存活率趋势的能力。这个开发的框架旨在填补单个细胞系在光子照射下作为NP浓度函数的反应的现有空白，并协助科学界规划未来高Z纳米粒子增强光子放疗的临床前试验。
A local effect model (LEM)-based framework capable of interpolating nanoparticle-enhanced photon-irradiated clonogenic cell survival fraction measurements as a function of nanoparticle concentration was developed and experimentally benchmarked for gold nanoparticle (AuNP)-doped bovine aortic endothelial cells (BAECs) under superficial kilovoltage X-ray irradiation. For three different superficial kilovoltage X-ray spectra, the BAEC survival fraction response was predicted for two different AuNP concentrations and compared to experimental data. The ability of the developed framework to predict the cell survival fraction trends is analysed and discussed. This developed framework is intended to fill in the existing gaps of individual cell line response as a function of NP concentration under photon irradiation and assist the scientific community in planning future pre-clinical trials of high Z nanoparticle-enhanced photon radiotherapy.