Effects of chronic nitric oxide synthase inhibition on endothelium-dependent and -independent relaxation in arteries that perfuse skeletal muscle of swine.
Effects of chronic nitric oxide synthase inhibition on endothelium-dependent and -independent relaxation in arteries that perfuse skeletal muscle of swine.
复制标题
慢性一氧化氮合酶抑制对灌注猪骨骼肌的动脉内皮依赖性和非依赖性松弛的影响。
DOI：
10.1080/10623320802092211
复制
发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Laughlin,MH
中科院分区：
文献类型：
--
作者：
Newcomer,SC;Taylor,JC;McAllister,RM;Laughlin,MH
本研究的目的是检验以下假设：慢性NG-硝基-L-精氨酸甲酯（L-NAME）处理对灌注猪骨骼肌的动脉中的管道动脉和阻力小动脉对内皮依赖性和非依赖性血管舒张剂的舒张反应产生不同的影响。为了检验这一假设，管道骨骼肌动脉和二级骨骼肌（2A）小动脉收获14尤卡坦猪长期给予L-NAME和16个对照。在导管和2A小动脉中进行血管舒张对增加剂量的乙酰胆碱（ACH）、缓激肽（BK）和硝普钠（SNP）的体外评估。L-NAME治疗显著降低了导管动脉中BK和ACH的舒张反应。相反，舒张反应和/或SNP的敏感性显着更大的完整，但不裸露，管道动脉环从长期L-NAME治疗的猪。慢性L-NAME治疗对骨骼肌小动脉的血管舒张没有显着影响。这些发现表明：（1）与小动脉不同，骨骼肌导管动脉不能通过上调替代血管舒张途径来功能性补偿NO的缺乏;（2）长期L-NAME治疗猪的导管动脉对SNP的更大舒张反应可以通过内皮的改变来解释。
The purpose of this investigation was to test the hypothesis that chronicNG-nitro-l-arginine methyl ester (l-NAME) treatment produces differential effects on conduit artery and resistance arteriole relaxation responses to endothelium-dependent and -independent vasodilators in arteries that perfuse skeletal muscle of swine. To test this hypothesis, conduit skeletal muscle arteries and second-order skeletal muscle (2A) arterioles were harvested from 14 Yucatan swine that were chronically administered l-NAME and from 16 controls. In vitro assessments of vasorelaxation to increasing doses of acetylcholine (ACH), bradykinin (BK), and sodium nitroprusside (SNP) were performed in both conduit and 2A arterioles. l-NAME treatment produced a significant reduction in both BK and ACH relaxation responses in the conduit arteries. In contrast, the relaxation response and/or sensitivity to SNP were significantly greater in the intact, but not denuded, conduit arterial rings from chronically l-NAME–treated swine. There were no significant effects of chronic l-NAME treatment on vasodilation of skeletal muscle arterioles. These findings suggest (1) that unlike arterioles, skeletal muscle conduit arteries do not functionally compensate for a lack of NO through the upregulation of alternative vasodilator pathways; (2) that the greater relaxation response in conduit arteries of chronically l-NAME–treated swine to SNP can be explained by alterations to the endothelium.
登录
查看更多内容
影响因子：
10.8
作者：
Kojda, G;Laursen, JB;Harrison, DG
通讯作者：
Harrison, DG
一氧化氮对培养物中牛内皮细胞释放前列环素的作用。
影响因子：
5
作者：
M. Doni;B. J. Whittle;R. Palmer;Salvador Moncada
通讯作者：
Salvador Moncada
一氧化氮和前列腺素在人类骨骼肌中的贡献的激动剂依赖性变异性。
DOI：
10.1152/japplphysiol.00966.2004
发表时间：
2005
期刊：
Journal of applied physiology (Bethesda, Md. : 1985)
影响因子：
--
作者：
Schrage,WilliamG;Dietz,NikiM;Eisenach,JohnH;Joyner,MichaelJ
通讯作者：
Joyner,MichaelJ
人体循环：身体压力期间的调节
DOI：
10.1001/jama.1987.03400220116052
发表时间：
1987
期刊：
JAMA
影响因子：
--
作者：
P. G. Iatridis
通讯作者：
P. G. Iatridis
一氧化氮和内皮衍生的超极化因子：形成和相互作用。
DOI：
--
发表时间：
1997
期刊：
Prostaglandins, Leukotrienes and Essential Fatty Acids
影响因子：
--
作者：
J. Bauersachs;R. Popp;I. Fleming;R. Busse
通讯作者：
R. Busse