Frailty: a tale of two concepts
Frailty: a tale of two concepts
复制标题
脆弱：两个概念的故事
作者：
J. Walston;K. Bandeen
对于临床医生来说，虚弱对于改善弱势老年人的护理越来越重要。主要的脆弱指标包括脆弱表型和脆弱指数。虚弱表型是建立在一个理论结构上的，该理论结构假设具有潜在的生物学基础。虚弱指数将虚弱描述为一种非特异性的与年龄相关的脆弱性，反映在医疗、社会和功能缺陷的积累上。在此模型的基础上，Minitski等人描述了一种生物指数的开发，与其他虚弱测量相比，该生物指数被证明是预测死亡率的合理方法。优势包括其导入临床措施、可互换组件的能力，以及识别潜在风险因素的潜在能力。障碍包括缺乏与衰老相关的统一生物学理论，包括昂贵的研究措施，以及无法根据虚弱指数定义提供虚弱病因学的具体线索。改进措施侧重于与衰老有关的生物变化，而不是使用慢性疾病状态导致的措施，可以帮助提供重要的生物学见解，并有助于开发未来的治疗和预防模式。http://www.biomedcentral.com/1741-7015/13/161
Frailty is increasingly relevant for clinicians to improve care for vulnerable older adults. Prominent frailty measures include the frailty phenotype and the frailty index. The frailty phenotype is grounded in a theoretical construct hypothesized to have an underlying biological basis. The frailty index describes frailty as a nonspecific age-associated vulnerability, reflected in an accumulation of medical, social, and functional deficits. Building on this model, Minitski et al. describe the development of a biological index that proves to be a reasonable method to predict mortality when compared to other frailty measurements. Strengths include its ability to import clinical measures, interchangeable components, and its potential ability to identify latent risk factors. Obstacles include the lack of a unifying biological theory related to aging, inclusion of costly research measures, and its inability to provide specific clues to the etiology of frailty according to the frailty index definition. Refinement in measures focused on aging-related biological changes rather than using measures that result from chronic disease states could help provide important biological insights and aid in the development of future treatment and preventive modalities.Please see related article: http://www.biomedcentral.com/1741-7015/13/161.
脆弱共识：行动呼吁。
DOI：
10.1016/j.jamda.2013.03.022
发表时间：
2013-06
影响因子：
7.6
作者：
Morley JE;Vellas B;van Kan GA;Anker SD;Bauer JM;Bernabei R;Cesari M;Chumlea WC;Doehner W;Evans J;Fried LP;Guralnik JM;Katz PR;Malmstrom TK;McCarter RJ;Gutierrez Robledo LM;Rockwood K;von Haehling S;Vandewoude MF;Walston J
通讯作者：
Walston J
影响因子：
24
作者：
Afilalo J;Alexander KP;Mack MJ;Maurer MS;Green P;Allen LA;Popma JJ;Ferrucci L;Forman DE
通讯作者：
Forman DE