VESTIBULAR FUNCTION IN PERIODIC ALTERNATING NYSTAGMUS
VESTIBULAR FUNCTION IN PERIODIC ALTERNATING NYSTAGMUS
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DOI：
10.1093/brain/113.5.1425
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发表时间：
1990-10-01
期刊：
影响因子：
14.5
通讯作者：
PANG, D
中科院分区：
文献类型：
--
作者：
FURMAN, JMR;WALL, C;PANG, D
本文对4例周期性交替性眼球震颤（PAN）患者的前庭眼反射进行了详细研究。旋转测试用于研究水平半规管-眼反射、耳石-耳道相互作用和动态耳石-眼反射。结果表明，异常增益和相位的水平半规管眼反射在正弦旋转和可变的衰减率的旋转后的反应。每例患者都有异常的耳道-耳石相互作用。在每例患者中观察到动态耳石-眼反应的放大调制分量。这项研究支持的想法，PAN是由速度存储元件，一个假设的神经回路，持续前庭和视动刺激的眼动反应的不稳定性。此外，我们推测PAN可能是由小脑悬雍垂和结节的病变或它们与脑干前庭核的连接引起的。
The vestibulo-ocular reflex of 4 patients with periodic alternating nystagmus (PAN) was studied in detail. Rotational testing was used to investigate the horizontal semicircular canal-ocular reflex, canal-otolith interaction, and the dynamic otolith-ocular reflex. Results indicated abnormal gain and phase of the horizontal semicircular canal-ocular reflex during sinusoidal rotation and a variable rate of decay of postrotatory responses. Each patient had abnormal canal-otolith interaction. An enlarged modulation component of the dynamic otolith-ocular response was observed in each patient. This study supports the idea that PAN is caused by an instability in the velocity storage element, a hypothetical neural circuit that perseverates the eye movement response to both vestibular and optokinetic stimulation. Further, we postulate that PAN may be caused by lesions of the cerebellar uvula and nodulus or their connections with the brainstem vestibular nuclei.