ATRIAL-NATRIURETIC-PEPTIDE ELEVATION IN CONGESTIVE-HEART-FAILURE IN THE HUMAN
ATRIAL-NATRIURETIC-PEPTIDE ELEVATION IN CONGESTIVE-HEART-FAILURE IN THE HUMAN
复制标题
DOI：
10.1126/science.2935937
复制
发表时间：
1986-03-07
期刊：
影响因子：
56.9
通讯作者：
REEDER, GS
中科院分区：
文献类型：
--
作者：
BURNETT, JC;KAO, PC;REEDER, GS
应用灵敏的心房钠素放射免疫分析法，研究了正常人、心血管疾病患者和心脏充血性压力正常的患者、心血管疾病患者和心脏充血性压力升高的患者（伴和不伴充血性心力衰竭）循环心房钠素与心脏充血性压力的关系。本研究建立了正常人心房利钠肽的正常范围。这些研究还证实，心脏充盈压升高与循环心房钠肽浓度升高有关，充血性心力衰竭的特征不是心房钠肽缺乏，而是心房钠肽升高。
A sensitive radioimmunoassay for atrial natriuretic peptide was used to examine the relation between circulating atrial natriuretic peptide and cardiac filling pressure in normal human subjects, in patients with cardiovascular disease and normal cardiac filling pressure, and in patients with cardiovascular disease and elevated cardiac filling pressure with and without congestive heart failure. The present studies establish a normal range for atrial natriuretic peptide in normal human subjects. These studies also establish that elevated cardiac filling pressure is associated with increased circulating concentrations of atrial natriuretic peptide and that congestive heart failure is not characterized by a deficiency in atrial natriuretic peptide, but with its elevation.