Chronic ethanol treatment leads to increased ornithine decarboxylase activity: implications for a role of polyamines in ethanol dependence and withdrawal.
Chronic ethanol treatment leads to increased ornithine decarboxylase activity: implications for a role of polyamines in ethanol dependence and withdrawal.
复制标题
慢性乙醇治疗导致鸟氨酸脱羧酶活性增加：对多胺在乙醇依赖和戒断中的作用的影响。
DOI：
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
P. Wilce
中科院分区：
文献类型：
--
作者：
M. Davidson;P. Wilce
Recent research has focused on the N-methyl-D-aspartate receptor system as a major site of ethanol action in the brain and specifically on compensatory changes in the expression of the polyamine-sensitive NR2B subunit. Therefore, we examined the effects of chronic ethanol treatment on polyamine homeostasis in the rat brain. Wistar rats were made dependent by ethanol vapor inhalation. This caused a rise in hippocampal ornithine decarboxylase (ODC) activity that was correlated with the appearance of physiological dependence. ODC activity returned to control levels within 3 days of ethanol withdrawal. Enzyme activity also increased in the cerebral cortex, striatum, and cerebellum of the ethanol-dependent rats. The concentration of the polyamines (putrescine, spermidine, and spermine) in the hippocampus was increased in ethanol-dependent rats. Injection of the ODC inhibitor, alpha-difluoromethylornithine (500 mg/kg) at the onset of withdrawal resulted in a significant reduction in the severity of withdrawal behaviors. The level of ODC activity and the severity of withdrawal behaviors were positively correlated. Perturbed polyamine homeostasis may represent an important molecular component in the initiation of ethanol withdrawal behaviors in the ethanol-dependent rat.
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DOI：
--
发表时间：
1982-09
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
T. Slotkin;F. Seidler;P. Trépanier;W. Whitmore;L. Lerea;G. Barnes;S. Weigel;J. Bartolome
通讯作者：
T. Slotkin;F. Seidler;P. Trépanier;W. Whitmore;L. Lerea;G. Barnes;S. Weigel;J. Bartolome
影响因子：
3.6
作者：
K. Williams;A. M. Zappia;D. B. Pritchett;Yu-Min Shen;P. Molinoff
通讯作者：
K. Williams;A. M. Zappia;D. B. Pritchett;Yu-Min Shen;P. Molinoff
乙醇抑制成骨细胞增殖和鸟氨酸脱羧酶活性。
影响因子：
4.8
作者：
Klein,RF;Carlos,AS
通讯作者：
Carlos,AS
多胺对 NMDA 受体的调节。
影响因子：
6.1
作者：
Williams,K;Romano,C;Dichter,MA;Molinoff,PB
通讯作者：
Molinoff,PB
乙醇对 NMDA、红藻氨酸和印防己毒素诱导的大鼠惊厥的抗惊厥作用比较。
影响因子：
6.1
作者：
Kulkarni,SK;Mehta,AK;Ticku,MK
通讯作者：
Ticku,MK