DASH-Style Diet Associates with Reduced Risk for Kidney Stones
DASH-Style Diet Associates with Reduced Risk for Kidney Stones
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DOI：
10.1681/asn.2009030276
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发表时间：
2009-10-01
影响因子：
13.6
通讯作者：
Curhan, Gary C.
中科院分区：
文献类型：
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作者：
Taylor, Eric N.;Fung, Teresa T.;Curhan, Gary C.
停止高血压饮食方法(DASH)对肾结石形成的影响尚不清楚。我们在健康专业人员随访研究(n=45,821名男性；18年随访)、护士健康研究I(n=94,108名老年女性；18年随访)和护士健康研究11(n=101,837名年轻女性；14年随访)中前瞻性地研究了短程饮食与肾结石发生的关系。我们根据水果、蔬菜、坚果和豆类的高摄入量、低脂乳制品、全谷物和低钠摄入量、含糖饮料以及红肉和加工肉的摄入量构建了一个DASH评分。我们使用COX风险回归对年龄、BMI和液体摄入量等因素进行调整。在总共50年的随访中，我们记录了5645例肾结石事件。DASH得分较高的参与者钙、钾、镁、草酸盐和维生素C的摄入量较高，而钠的摄入量较低。对于DASH得分最高和最低五分之一的参与者，肾结石的多变量相对危险度男性为0.55(95%CI，0.46至0.65)，老年女性为0.58(95%CI，0.49至0.68)，年轻女性为0.60(95%CI，0.52至0.70)。即使在钙摄入量较低的参与者中，DASH得分较高也与风险降低有关。排除患有高血压的参与者并没有改变结果。总而言之，进食DASH式饮食与显著降低肾结石风险有关。
The impact of the Dietary Approaches to Stop Hypertension (DASH) diet on kidney stone formation is unknown. We prospectively examined the relation between a DASH-style diet and incident kidney stones in the Health Professionals Follow-up Study (n = 45,821 men; 18 yr of follow-up), Nurses' Health Study I (n = 94,108 older women; 18 yr of follow-up), and Nurses' Health Study 11 (n = 101,837 younger women; 14 yr of follow-up). We constructed a DASH score based on eight components: high intake of fruits, vegetables, nuts and legumes, low-fat dairy products, and whole grains and low intake of sodium, sweetened beverages, and red and processed meats. We used Cox hazards regression to adjust for factors that included age, BMI, and fluid intake. Over a combined 50 yr of follow-up, we documented 5645 incident kidney stones. Participants with higher DASH scores had higher intakes of calcium, potassium, magnesium, oxalate, and vitamin C and had lower intakes of sodium. For participants in the highest compared with the lowest quintile of DASH score, the multivariate relative risks for kidney stones were 0.55 (95% Cl, 0.46 to 0.65) for men, 0.58 (95% Cl, 0.49 to 0.68) for older women, and 0.60 (95% Cl, 0.52 to 0.70) for younger women. Higher DASH scores were associated with reduced risk even in participants with lower calcium intake. Exclusion of participants with hypertension did not change the results. In conclusion, consumption of a DASH-style diet is associated with a marked decrease in kidney stone risk.