Philadelphia-positive T-ALL in a patient with follicular lymphoma
Philadelphia-positive T-ALL in a patient with follicular lymphoma
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DOI：
10.1038/sj.bmt.1702670
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发表时间：
2000-11-01
影响因子：
4.8
通讯作者：
Milligan, DW
中科院分区：
文献类型：
--
作者：
Auer, RL;Oates, J;Milligan, DW
滤泡性淋巴瘤是一种B细胞恶性肿瘤，易于转化为大细胞弥漫性组织学，这种进展可能是多克隆的，如IgH重排所确定的。在免疫功能低下的患者中也描述了类似的多克隆发生。然而，淋巴瘤细胞仍然主要是B细胞类型。滤泡性淋巴瘤引起的弥漫性T细胞复合性淋巴瘤很少见。在既存B细胞恶性肿瘤患者中发生T细胞白血病是极其罕见的事件。滤泡性淋巴瘤（FL）后发生T细胞急性淋巴细胞白血病（T-ALL）以前没有报道。我们报告了一例费城阳性（Ph+）T细胞ALL的患者谁以前有FL，这可能会给一些了解细胞的起源和缺陷负责淋巴细胞的恶性转化的发展。
Follicular lymphoma is a B cell malignancy prone to transformation into a large cell diffuse histology, This progression may be multi-clonal as determined by IgH rearrangement. Similar multi-clonal occurrences have been described in immunocompromised patients. However, the lymphoma cells remain predominantly of B cell type. Rarely, composite lymphomas with diffuse T cell histology have been reported arising from follicular lymphoma. The development of T cell leukaemia in a patient with a pre-existing B cell malignancy is an extremely rare event. The occurrence of T cell acute lymphoblastic leukaemia (T-ALL) following follicular lymphoma (FL) has not previously been reported. We report a case of Philadelphia positive (Ph+) T cell ALL developing in a patient who previously had FL which may give some insight into the cell of origin and the defects responsible for malignant transformation of the lymphocytes.