Metabolic syndrome as a precursor of cardiovascular disease and type 2 diabetes mellitus
Metabolic syndrome as a precursor of cardiovascular disease and type 2 diabetes mellitus
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DOI：
10.1161/circulationaha.105.539528
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发表时间：
2005-11-15
期刊：
影响因子：
37.8
通讯作者：
Meigs, JB
中科院分区：
文献类型：
--
作者：
Wilson, PWF;D'Agostino, RB;Meigs, JB
背景——心血管疾病（CVD）、冠心病（CHD）和2型糖尿病（T2DM）的发病率在代谢综合征（至少有以下3种：腹部肥胖、低高密度脂蛋白胆固醇、高甘油三酯、高血压和空腹血糖受损）患者中尚未明确定义。目的是根据代谢综合征特征调查CVD、CHD和T2DM的风险。方法和结果：该研究随访了3323名中年人，在8年的时间里，研究了新的心血管疾病、冠心病和2型糖尿病的发展情况。在基线时没有CVD或T2DM的人群中，代谢综合征（5个特征中bb0 = 3）的患病率在男性中为26.8%，在女性中为16.6%。心血管疾病174例，冠心病107例，2型糖尿病178例。在男性中，心血管疾病代谢综合征年龄调整相对危险度（RR）和95% CI分别为：心血管疾病RR = 2.88 (95% CI 1.99 ~ 4.16)，冠心病RR = 2.54 (95% CI 1.62 ~ 3.98), T2DM RR = 6.92 （95% CI 4.47 ~ 10.81）。心血管疾病（RR = 2.25, 95% CI 1.31 - 3.88）和冠心病（RR = 1.54, 95% CI 0.68 - 3.53）的发生率和RR较低，但T2DM的发生率和RR相似（RR = 6.90, 95% CI 4.34 - 10.94）。与CVD、CHD和T2DM代谢综合征相关的人群归因风险估计在男性中分别为34%、29%和62%，在女性中分别为16%、8%和47%。结论：代谢综合征是常见的，并且在两性中与CVD和T2DM的风险增加有关。在8年的随访中，代谢综合征占男性心血管疾病的三分之一，约占新发T2DM的一半。
Background - The incidence of cardiovascular disease ( CVD), coronary heart disease ( CHD), and type 2 diabetes mellitus ( T2DM) has not been well defined in persons with the metabolic syndrome ( at least 3 of the following: abdominal adiposity, low HDL cholesterol, high triglycerides, hypertension, and impaired fasting glucose). The objective was to investigate risk for CVD, CHD, and T2DM according to metabolic syndrome traits.Methods and Results - The study followed a cohort of 3323 middle-aged adults for the development of new CVD, CHD, and T2DM over an 8-year period. In persons without CVD or T2DM at baseline, the prevalence of the metabolic syndrome ( >= 3 of 5 traits) was 26.8% in men and 16.6% in women. There were 174 incident cases of CVD, 107 of CHD, and 178 of T2DM. In men, the metabolic syndrome age-adjusted relative risk ( RR) and 95% CIs were RR = 2.88 ( 95% CI 1.99 to 4.16) for CVD, RR = 2.54 ( 95% CI 1.62 to 3.98) for CHD, and RR = 6.92 ( 95% CI 4.47 to 10.81) for T2DM. Event rates and RRs were lower in women for CVD ( RR = 2.25, 95% CI 1.31 to 3.88) and CHD ( RR = 1.54, 95% CI 0.68 to 3.53), but they were similar for T2DM ( RR = 6.90, 95% CI 4.34 to 10.94). Population-attributable risk estimates associated with metabolic syndrome for CVD, CHD, and T2DM were 34%, 29%, and 62% in men and 16%, 8%, 47% in women.Conclusions - Metabolic syndrome is common and is associated with an increased risk for CVD and T2DM in both sexes. The metabolic syndrome accounts for up to one third of CVD in men and approximately half of new T2DM over 8 years of follow-up.