Comparison of the Atkins, Zone, Ornish, and LEARN diets for change in weight and related risk factors among overweight premenopausal women
Comparison of the Atkins, Zone, Ornish, and LEARN diets for change in weight and related risk factors among overweight premenopausal women
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DOI：
10.1001/jama.297.9.969
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发表时间：
2007-03-07
影响因子：
120.7
通讯作者：
King, Abby C.
中科院分区：
文献类型：
--
作者：
Gardner, Christopher D.;Kiazand, Alexandre;King, Abby C.
背景流行的饮食，特别是那些低碳水化合物的饮食，已经挑战了目前的建议，建议低脂肪，高碳水化合物的饮食减肥。目的比较4种不同碳水化合物摄入量的减肥饮食对减肥效果及相关代谢变量的影响。设计、设置和参与者：2003年2月至2005年10月在美国进行为期10个月的随机试验，纳入311名自由生活的超重/肥胖者干预参与者被随机分配遵循阿特金斯（n=77）、Zone（n= 79）、LEARN（n = 79）或Ornish（n= 76）饮食，并接受每周指导，持续2个月，然后进行额外的10个月随访。主要结果测量12个月时的体重减轻是主要结果。次要结果包括血脂（低密度脂蛋白、高密度脂蛋白、非高密度脂蛋白胆固醇和甘油三酯水平）、体脂百分比、腰臀比、空腹胰岛素和血糖水平以及血压。在第0、2、6和12个月评估结局。结果与其他饮食组相比，阿特金斯饮食组的女性在12个月时的体重减轻更大，并且阿特金斯和Zone饮食组之间的平均12个月体重减轻显著不同（P
Context Popular diets, particularly those low in carbohydrates, have challenged current recommendations advising a low-fat, high-carbohydrate diet for weight loss. Potential benefits and risks have not been tested adequately.Objective To compare 4 weight-loss diets representing a spectrum of low to high carbohydrate intake for effects on weight loss and related metabolic variables.Design, Setting, and Participants Twelve-month randomized trial conducted in the United States from February 2003 to October 2005 among 311 free-living, over-weight/ obese ( body mass index, 27-40) nondiabetic, premenopausal women.Intervention Participants were randomly assigned to follow the Atkins (n=77), Zone (n=79), LEARN (n=79), or Ornish (n= 76) diets and received weekly instruction for 2 months, then an additional 10-month follow-up.Main Outcome Measures Weight loss at 12 months was the primary outcome. Secondary outcomes included lipid profile (low-density lipoprotein, high-density lipoprotein, and non-high-density lipoprotein cholesterol, and triglyceride levels), percentage of body fat, waist-hip ratio, fasting insulin and glucose levels, and blood pressure. Outcomes were assessed at months 0, 2, 6, and 12. The Tukey studentized range test was used to adjust for multiple testing.Results Weight loss was greater for women in the Atkins diet group compared with the other diet groups at 12 months, and mean 12-month weight loss was significantly different between the Atkins and Zone diets ( P