EFFECT OF MAJOR MOTOR SEIZURE FREQUENCY UPON COGNITIVE-INTELLECTUAL FUNCTIONS IN ADULTS
EFFECT OF MAJOR MOTOR SEIZURE FREQUENCY UPON COGNITIVE-INTELLECTUAL FUNCTIONS IN ADULTS
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DOI：
10.1111/j.1528-1157.1977.tb05583.x
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发表时间：
1977-01-01
期刊：
影响因子：
5.6
通讯作者：
MATTHEWS, CG
中科院分区：
文献类型：
--
作者：
DIKMEN, S;MATTHEWS, CG
对3组发作频率不同的成年运动性癫痫患者进行了韦氏成人智力量表和Halstead神经心理测验。各组在癫痫发作持续时间和发病年龄变量上相等。在14项心理测量中的7项上，分别获得了高、中、低癫痫发作频率组的显著组间差异。对另外2个组进行了类似的性能比较：高风险组的特征是发病年龄早、癫痫发作持续时间长和癫痫发作频率高，低风险组的特征是发病年龄晚、癫痫发作持续时间短和癫痫发作频率低。在14个变量中的12个变量上，高风险组和低风险组之间存在高度显著性差异，高风险组表现出严重的认知和适应障碍。主要运动性癫痫发作频率的增加与适应性障碍水平的增加有关。当癫痫发作频率高并伴有早发和病程长的病史时，严重认知适应性功能障碍的可能性显著增加。
Wechsler Adult Intelligence Scale and Halstead neuropsychological performances were investigated in 3 groups of adult subjects [Ss] with major motor epilepsy classified according to low, moderate and high seizure frequency. The groups were equated on seizure duration and age at onset variables. On 7 of the 14 psychological measures employed, significant between-group differences were obtained, with the high, moderate and low seizure frequency groups, respectively. Similar performance comparisons were made on 2 additional groups: a high risk group characterized by early onset age, long seizure duration and high seizure frequency, and a low risk group characterized by late onset age, short seizure duration and low seizure frequency. Highly significant differences were obtained between the high risk and low risk groups on 12 of 14 variables, with the high risk Ss demonstrating severe cognitive and adaptive impairment. Increased frequency of major motor seizures was associated with increasing levels of adaptive impairments. The probability of severe cognitive-adaptive dysfunction was substantially increased when high seizure frequency was accompanied by a history of early onset and long duration of the disorder.