Abstract MP57: Lactation Duration is Associated With Lower Visceral and Pericardial Fat Volumes in Parous Women: 25-year Follow-up in the Cardia Study
Abstract MP57: Lactation Duration is Associated With Lower Visceral and Pericardial Fat Volumes in Parous Women: 25-year Follow-up in the Cardia Study
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摘要 MP57：哺乳期持续时间与经产妇女较低的内脏和心包脂肪体积相关：心脏研究的 25 年随访
DOI：
10.1161/circ.141.suppl_1.mp57
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发表时间：
2020
期刊：
影响因子：
37.8
通讯作者：
E. Gunderson
中科院分区：
文献类型：
--
作者：
D. Appiah;C. Lewis;J. Carr;M. Gross;D. Jacobs;S. Sidney;J. Shikany;C. Quesenberry;E. Gunderson
导言：
哺乳与女性发生2型糖尿病和心血管疾病(CVD)的风险较低有关。然而，这些关联的潜在机制还没有被很好地理解。哺乳期和母体脂肪体积之间的纵向联系很少被研究。
假设：
我们测试了哺乳时间与母体内脏和心包脂肪体积成反比的假设。
方法：
数据来自910名参加青年冠状动脉风险发展研究(1985年至1986年)的怀孕前无糖尿病的妇女，她们在25年的随访中生下了≥1。所有新生儿自基线以来的累计哺乳期是根据每次检查时收集的自我报告计算出来的。在2010-2011年的25年考试中，通过计算机断层扫描测量了内脏和心包脂肪组织的体积。
方法：
在基线时，女性(48%黑人，52%白人)的平均年龄为24岁(范围：18-30岁)。在25年的随访中，76%的妇女报告哺乳持续时间为≥1个月。在调整后的线性回归模型中，哺乳时间与内脏脂肪(p=0.021)和心包脂肪(p=0.001)呈负相关(表)。种族和哺乳对内脏(p=0.035)和心包脂肪(p=0.027)体积有显著的交互作用(表)。正式中介分析表明，哺乳时间对内脏(p=0.001)和心包脂肪(p=0.002)体积有显著的间接影响，这是通过基线出生后第一次出生到随访结束之间的体重变化来实现的。体重的变化在哺乳时间与内脏和心包脂肪体积之间的关系中起到了29.4%和26.0%的中介作用。
结论：
在这项前瞻性研究中，较长的哺乳时间与较低的内脏和心包脂肪体积之间的关系部分是通过体重变化来调节的。
Introduction:
Lactation has been associated with a lower risk of incident type 2 diabetes mellitus and cardiovascular disease (CVD) in women. However, the underlying mechanisms for these associations are not well understood. The longitudinal association between lactation and maternal fat volume has rarely been investigated.
Hypothesis:
We tested the hypothesis that lactation duration is inversely associated with maternal visceral and pericardial fat volumes.
Methods:
Data were obtained from 910 women enrolled in the Coronary Artery Risk Development in Young Adults (CARDIA) study (1985-86) without diabetes prior to pregnancy who had ≥1 birth during 25 years of follow-up. Cumulative lactation duration across all births since baseline was calculated from self-reports collected at each exam. Volumes of visceral and pericardial adipose tissue were measured from computed tomographic scans at the Year 25 exam in 2010-2011.
Methods:
At baseline, the average age of women (48% black, 52% white) was 24 years (range: 18-30 years). During 25 years of follow-up, 76% of women reported lactation duration of ≥ 1 month. In adjusted linear regression models, lactation duration was inversely associated with visceral fat (p=0.021) and pericardial fat (p=0.001) volumes (Table). There was a significant interaction between race and lactation on visceral (p=0.035) and pericardial fat (p=0.027) volumes (Table). Formal mediation analysis showed a significant indirect effect of lactation duration on visceral (p=0.001) and pericardial fat (p=0.002) volumes through body weight change between the first postbaseline birth and the end of follow-up. Changes in body weight mediated 29.4% and 26.0% of the association between lactation duration and visceral and pericardial fat volumes.
Conclusions:
In this prospective study, the associations of longer lactation duration with lower visceral and pericardial fat volumes were partially mediated by body weight changes.