Ancient deuterostome origins of vertebrate brain signalling centres.
Ancient deuterostome origins of vertebrate brain signalling centres.
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DOI：
10.1038/nature10838
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发表时间：
2012-03-14
期刊：
影响因子：
64.8
通讯作者：
Lowe CJ
中科院分区：
文献类型：
--
作者：
Pani AM;Mullarkey EE;Aronowicz J;Assimacopoulos S;Grove EA;Lowe CJ
神经外胚层信号中心诱导和图案许多新的脊椎动物的大脑结构，但在无脊椎动物脊索动物缺席，或分歧。这导致了一种假设，即信号中心的遗传程序首先在干脊椎动物中组装，这可能推动了形态学的创新。然而，这种情况下假设现存的头索动物准确地代表祖先的脊索动物的字符，这还没有被测试使用密切的脊索动物外群。在这里，我们报告说，遗传程序同源的三个脊椎动物信号中心，前神经脊，丘脑内，和峡部组织者是存在于半索动物Saccoglossus kowalevskii。fgf 8/17/18，sfrp 1/5，hh和wnt 1在半脊索动物外胚层中以脊椎动物样排列表达，同源遗传机制调节两种动物的外胚层模式。我们建议这些遗传程序的组件出乎意料的复杂，古老的遗传调控支架后口体图案退化文昌鱼和海鞘，但保留图案分歧的结构在半索动物和脊椎动物。
Neuroectodermal signalling centres induce and pattern many novel vertebrate brain structures but are absent, or divergent, in invertebrate chordates. This has led to the hypothesis that signalling centre genetic programs were first assembled in stem vertebrates, which potentially drove morphological innovations. However, this scenario presumes that extant cephalochordates accurately represent ancestral chordate characters, which has not been tested using close chordate outgroups. Here, we report that genetic programs homologous to three vertebrate signalling centres; the anterior neural ridge, zona limitans intrathalamica, and isthmic organizer are present in the hemichordate Saccoglossus kowalevskii. Fgf8/17/18, sfrp1/5, hh, and wnt1 are expressed in vertebrate-like arrangements in hemichordate ectoderm, and homologous genetic mechanisms regulate ectodermal patterning in both animals. We propose these genetic programs were components of an unexpectedly complex, ancient genetic regulatory scaffold for deuterostome body patterning that degenerated in amphioxus and ascidians, but was retained to pattern divergent structures in hemichordates and vertebrates.
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影响因子：
9.8
作者：
Lowe CJ;Terasaki M;Wu M;Freeman RM Jr;Runft L;Kwan K;Haigo S;Aronowicz J;Lander E;Gruber C;Smith M;Kirschner M;Gerhart J
通讯作者：
Gerhart J
DOI：
10.1073/pnas.1014235108
发表时间：
2011-05-31
影响因子：
11.1
作者：
Bertrand, Stephanie;Camasses, Alain;Escriva, Hector
通讯作者：
Escriva, Hector
影响因子：
64.5
作者：
Lowe, CJ;Wu, M;Kirschner, M
通讯作者：
Kirschner, M
影响因子：
4.6
作者：
Imai, Kaoru S.;Stolfi, Alberto;Satou, Yutaka
通讯作者：
Satou, Yutaka
影响因子：
5.8
作者：
Larkin, M. A.;Blackshields, G.;Higgins, D. G.
通讯作者：
Higgins, D. G.