Slow axonal transport and the genesis of neuronal morphology
Slow axonal transport and the genesis of neuronal morphology
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DOI：
10.1002/neu.10281
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发表时间：
2004-01-01
期刊：
影响因子：
--
通讯作者：
Buster, DW
中科院分区：
文献类型：
--
作者：
Baas, PW;Buster, DW
关于慢轴突运输的经典观点认为，微管、神经丝和肌动蛋白丝沿着轴突相对连贯地向下移动，其速度明显慢于已知马达蛋白的特征。最近的研究表明，这些细胞骨架聚合物的运动实际上是快速的，异步的，间歇性的，最有可能是由熟悉的马达，如驱动蛋白，肌球蛋白和细胞质动力蛋白。这一新的观点得到了活细胞成像和机制分析的支持，表明缓慢的轴突运输既快速又具有可塑性，因此可能是神经元形态转变的基础。(C)2003 Wiley Periodicals，Inc.
The classic view of slow axonal transport maintains that microtubules, neurofilaments, and actin filaments move down the axon relatively coherently at rates significantly slower than those characteristic of known motor proteins. Recent studies indicate that the movement of these cytoskeletal polymers is actually rapid, asynchronous, intermittent, and most probably fueled by familiar motors such as kinesins, myosins, and cytoplasmic dynein. This new view, which is supported by both live-cell imaging and mechanistic analyses, suggests that slow axonal transport is both rapid and plastic, and hence could underlie transformations in neuronal morphology. (C) 2003 Wiley Periodicals, Inc.