Radiogenomic analysis reveals tumor heterogeneity of triple-negative breast cancer.
Radiogenomic analysis reveals tumor heterogeneity of triple-negative breast cancer.
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放射基因组学分析揭示三阴性乳腺癌的肿瘤异质性
DOI：
10.1016/j.xcrm.2022.100694
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发表时间：
2022-07-19
影响因子：
14.3
通讯作者：
Shao, Zhi-Ming
中科院分区：
文献类型：
--
作者：
Jiang, Lin;You, Chao;Xiao, Yi;Wang, He;Su, Guan-Hua;Xia, Bing-Qing;Zheng, Ren-Cheng;Zhang, Dan-Dan;Jiang, Yi-Zhou;Gu, Ya-Jia;Shao, Zhi-Ming
三阴性乳腺癌（TNBC）是具有不良预后和显著肿瘤异质性的乳腺癌的子集。在这里，我们从对比增强的磁共振图像中提取定量放射组学特征，以构建乳腺癌放射组学数据集（n = 860）和TNBC放射基因组学数据集（n = 202）。我们开发并验证了可以公平区分TNBC与其他乳腺癌亚型并区分TNBC内分子亚型的放射组学特征。捕获肿瘤周围异质性的放射组学特征被确定为TNBC中无复发生存期（p = 0.01）和总生存期（p = 0.004）的预后因素。结合已建立的匹配TNBC转录组学和代谢组学数据，我们证明肿瘤周围异质性与肿瘤样品中的免疫抑制和上调脂肪酸合成相关。总的来说，这个多组学数据集作为一个有用的公共资源，以促进TNBC的精确亚型，并有助于理解放射组学的生物学意义。放射组学特征识别TNBC与乳腺癌的其他亚型放射组学特征预测TNBC分子亚型反映肿瘤周围异质性的放射组学特征指示TNBC预后肿瘤周围异质性与TNBC中的代谢和免疫异常相关。研究放射组学作为评估三阴性乳腺癌（TNBC）肿瘤异质性的非侵入性方法。他们的研究利用放射组学特征来区分TNBC的肿瘤间异质性，并确定反映肿瘤周围异质性的预后放射组学特征，以与TNBC中的免疫抑制和代谢重编程相关。
Triple-negative breast cancer (TNBC) is a subset of breast cancer with an adverse prognosis and significant tumor heterogeneity. Here, we extract quantitative radiomic features from contrast-enhanced magnetic resonance images to construct a breast cancer radiomic dataset (n = 860) and a TNBC radiogenomic dataset (n = 202). We develop and validate radiomic signatures that can fairly differentiate TNBC from other breast cancer subtypes and distinguish molecular subtypes within TNBC. A radiomic feature that captures peritumoral heterogeneity is determined to be a prognostic factor for recurrence-free survival (p = 0.01) and overall survival (p = 0.004) in TNBC. Combined with the established matching TNBC transcriptomic and metabolomic data, we demonstrate that peritumoral heterogeneity is associated with immune suppression and upregulated fatty acid synthesis in tumor samples. Collectively, this multi-omic dataset serves as a useful public resource to promote precise subtyping of TNBC and helps to understand the biological significance of radiomics. A radiomic signature identifies TNBC from other subtypes of breast cancer Radiomic features are predictive of TNBC molecular subtypes A radiomic feature reflecting peritumoral heterogeneity indicates TNBC prognosis Peritumoral heterogeneity correlates with metabolic and immune abnormalities in TNBC Jiang et al. investigate radiomics as a non-invasive approach for evaluating tumor heterogeneity in triple-negative breast cancer (TNBC). Their study utilizes radiomic features to distinguish the intertumoral heterogeneity of TNBC and identify a prognostic radiomic feature reflecting peritumoral heterogeneity to correlate with immune suppression and metabolic reprogramming in TNBC.
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DOI：
10.1186/s13058-017-0846-1
发表时间：
2017-05-18
期刊：
Breast cancer research : BCR
影响因子：
--
作者：
Braman NM;Etesami M;Prasanna P;Dubchuk C;Gilmore H;Tiwari P;Plecha D;Madabhushi A
通讯作者：
Madabhushi A
三阴性乳腺癌的基因组和转录组景观：亚型和治疗策略
影响因子：
50.3
作者：
Jiang, Yi-Zhou;Ma, Ding;Shao, Zhi-Ming
通讯作者：
Shao, Zhi-Ming
分子亚型分析和基因组分析拓展了难治性转移性三阴性乳腺癌的精准医疗：FUTURE 试验
影响因子：
44.1
作者：
Jiang YZ;Liu Y;Xiao Y;Hu X;Jiang L;Zuo WJ;Ma D;Ding J;Zhu X;Zou J;Verschraegen C;Stover DG;Kaklamani V;Wang ZH;Shao ZM
通讯作者：
Shao ZM
影响因子：
19.7
作者：
Kim, Jae-Hun;Ko, Eun Sook;Nam, Seok Jin
通讯作者：
Nam, Seok Jin
影响因子：
168.9
作者：
Denkert, Carsten;Liedtke, Cornelia;von Minckwitz, Gunter
通讯作者：
von Minckwitz, Gunter