N-nitrosodimethylamine formation potential (NDMA-FP) of ranitidine remains after chlorination and/or photo-irradiation: Identification of transformation products in combination with NDMA-FP test
N-nitrosodimethylamine formation potential (NDMA-FP) of ranitidine remains after chlorination and/or photo-irradiation: Identification of transformation products in combination with NDMA-FP test
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DOI：
10.1016/j.chemosphere.2020.129200
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发表时间：
2021-03-01
期刊：
影响因子：
8.8
通讯作者：
Nakada, Norihide
中科院分区：
文献类型：
--
作者：
Zhao, Bo;Zhou, Jiajun;Nakada, Norihide
组胺H2受体拮抗剂雷尼替丁（RNTD）经氯胺化后，可生成高摩尔产率的消毒副产物N-亚硝基二甲胺（NDMA）。虽然RNTD和它的一些转化产物（TPs）已经在氯化和光照射下进行了研究，但RNTD TPs和NDMA形成潜力（NDMA-FP）之间的关系仍然不清楚。本研究探讨氯化和/或光照射的影响NDMA-FP来自RNTD，模拟城市水环境接受处理后的废水。RNTD经氯化和/或光照处理后，用液相色谱-四极杆飞行时间质谱（LC-QTof-MS）鉴定了10个TP，其中包括5个新的TP。此外，负责NDMA-FP的重要RNTD TP（例如，氯化和羟基化的RNTD：TP-364）也通过检测的峰面积与NDMA-FP之间的关系得到证实。结果表明，由于RNTD TP的存在，NDMA-FP仍然存在，尽管RNTD本身被氯化和/或光照射显著去除。TP-364仅通过RNTD的氯化形成，并且不能通过光照射去除。TP-314（RNTD的立体异构体）、TP-299和TP-286与NDMA-FP呈强正相关（R-2 > 0.90; F检验，P < 0.01），TP-314主要由RNTD的光照射生成，而氯化后的光照射不生成。(C)2020爱思唯尔有限公司版权所有。
N-nitrosodimethylamine (NDMA), a probable carcinogenic disinfection by-product, can be formed with high molar yields following chloramination of ranitidine (RNTD), a histamine H 2 -receptor antagonist. Although RNTD and some of its transformation products (TPs) have been studied under chlorination and photo-irradiation, the relationship between RNTD TPs and NDMA formation potential (NDMA-FP) remaining after those processes is still unclear. This study investigated the effects of chlorination and/or photo-irradiation on NDMA-FP derived from RNTD, simulating an urban water environment receiving treated wastewater. After chlorination and/or photo-irradiation of RNTD, ten TPs including five new ones were identified by liquid chromatography-quadrupole time-of-flight mass spectrometry (LC-QTof-MS). In addition, important RNTD TPs responsible for NDMA-FP (e.g., chlorinated and hydroxylated RNTD: TP-364) were also confirmed by the relationship between detected peak area and NDMA-FP. The results showed that NDMA-FP remained due to the presence of RNTD TPs, although RNTD itself was significantly removed by chlorination and/or photo-irradiation. TP-364 was only formed by chlorination of RNTD and could not be removed by photo-irradiation. TP-314 (a stereoisomer of RNTD), -299, and -286, which were mainly formed by photo-irradiation of RNTD but not by photo-irradiation after chlorination, had strong positive correlations with NDMA-FP (R-2 > 0.90; F-test, P < 0.01). (C) 2020 Elsevier Ltd. All rights reserved.