The cerebellum is involved in predicting the sensory consequences of action
The cerebellum is involved in predicting the sensory consequences of action
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DOI：
10.1097/00001756-200107030-00023
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发表时间：
2001-07-03
期刊：
影响因子：
1.7
通讯作者：
Wolpert, DM
中科院分区：
文献类型：
--
作者：
Blakemore, SJ;Frith, CD;Wolpert, DM
我们使用（H2O）-O-15 PET检查神经反应的预测和实际的感觉运动的后果之间的差异程度的参数变化。受试者用右手移动一个机械臂，这个机械臂的运动决定了第二个泡沫尖端机械臂的位置，第二个泡沫尖端机械臂与受试者的左手掌接触。使用这种机器人接口，在右手的运动和左手的触觉刺激之间引入了计算机控制的延迟。右侧小脑皮质的活动与延迟呈正相关。这些结果表明，小脑参与了运动的预测和实际感觉结果之间的感觉差异的信号。NeuroReport 12：1879-1884（C）2001 Lippincott威廉姆斯& Wilkins.
We used (H2O)-O-15 PET to examine neural responses to parametrically varied degrees of discrepancy between the predicted and actual sensory consequences of movement. Subjects used their right hand to move a robotic arm. The motion of this robotic arm determined the position of a second foam-tipped robotic arm, which made contact with the subject's left palm. Using this robotic interface, computer controlled delays were introduced between the movement of the right hand and the tactile stimulation on the left. Activity in the right lateral cerebellar cortex showed a positive correlation with delay. These results suggest the cerebellum is involved in signalling the sensory discrepancy between the predicted and actual sensory consequences of movements. NeuroReport 12:1879-1884 (C) 2001 Lippincott Williams & Wilkins.