Bacteriological pathogen spectrum of chronic leg ulcers: Results of a multicenter trial in dermatologic wound care centers differentiated by regions
Bacteriological pathogen spectrum of chronic leg ulcers: Results of a multicenter trial in dermatologic wound care centers differentiated by regions
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DOI：
10.1111/ddg.12170
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发表时间：
2013-11-01
影响因子：
3.6
通讯作者：
Dissemond, Joachim
中科院分区：
文献类型：
--
作者：
Jockenhoefer, Finja;Gollnick, Harald;Dissemond, Joachim
背景资料：在几乎每一个慢性伤口不同的细菌物种可以检测到patients and methods：回顾性，多中心评价细菌拭子结果从2010年和2011年在慢性腿部溃疡患者治疗的10个皮肤科伤口护理中心从5个地区在德国。47.6%的患者检出金黄色葡萄球菌，其中8.6%为耐甲氧西林（MRSA）。铜绿假单胞菌占31.1%，肠杆菌占28.6%，奇异变形杆菌占13.7%.区域比较显示，S.金黄色葡萄球菌、铜绿假单胞菌和肠杆菌。此外，MRSA的西-东梯度非常显著，西部的检出率为13.5%，东部为4.0%。此外，在全国范围内，S。金黄色葡萄球菌和铜绿假单胞菌或奇异假单胞菌，以及铜绿假单胞菌与伤口大小和持续时间呈正相关。除了气候和治疗条件，不同的区域卫生保健结构进行了讨论，这些显着不同的区域检测率的潜在相关原因。结论：我们的数据显示，目前在德国慢性腿部溃疡患者检测到的细菌谱的区域变异性。
Background: In almost every chronic wound different bacteria species can be detected.Patients and methods: Retrospective, multicenter evaluation of bacterial swab results from 2010 and 2011 in patients with chronic leg ulcer treated in 10 dermatologic wound care centers from 5 regions in Germany.Results: Data of 970 patients were analyzed. Staphylococcus aureus was detected in 47.6 % of the patients, 8.6 % of these were methicillin-resistant (MRSA). Pseudomonas aeruginosa was found in 31.1 %, enterobacteria in 28.6 % and Proteus mirabilis in 13.7 % of the patients. The regional comparison showed a significant south-north gradient for S. aureus, P. aeruginosa, and enterobacteria. Moreover, a highly significant west-east gradient for MRSA was found with detection rates of 13.5 % in the west to 4.0 % in the east. Furthermore, nationally there was a significant negative correlation between S. aureus and P. aeruginosa or P. mirabilis, respectively, as well as a positive correlation of P. aeruginosa with respect to wound size and duration. In addition to climatic and therapeutic conditions, different regional health care structures are discussed as potentially relevant reasons for these significantly different regional detection rates.Conclusions: Our data show the regional variability of the spectrum of currently detected bacteria in patients with chronic leg ulcers in Germany.