The Quantitative Measurements of Vascular Density and Flow Areas of Macula Using Optical Coherence Tomography Angiography in Normal Volunteers
The Quantitative Measurements of Vascular Density and Flow Areas of Macula Using Optical Coherence Tomography Angiography in Normal Volunteers
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DOI：
10.3928/23258160-20170601-06
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发表时间：
2017-06-01
影响因子：
1
通讯作者：
Sabour, Siamak
中科院分区：
文献类型：
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作者：
Ghassemi, Fariba;Fadakar, Kaveh;Sabour, Siamak
背景与目的：应用光学相干断层扫描血管成像技术(OCTA)对健康人黄斑中心凹及黄斑旁区域的血流区及黄斑血管网密度进行定量研究。纳入112名没有已知眼部或全身疾病的正常志愿者，包括患者数量(单眼或双眼)、选择程序、纳入/排除标准、随机化程序和掩蔽。在以黄斑为中心的3 mm×3 mm区域行面部血管造影OCTA。使用自动阈值和测量算法测量中心凹和中心凹旁血流及血管密度(Vd)。测量黄斑血管网密度和黄斑中心凹及黄斑旁区域的血流面积。结果：共纳入112例(224只眼)健康眼，平均年龄36.4岁+/-11.3岁。在中心凹区域，浅层毛细血管网(SCN)的Vd明显高于深层毛细血管网(DCN)(31.1%±5.5%vs.28.3%±7.2%；P&t；.001)，而DCN的Vd(62.24%±2.8%vs.56.5%+/-2.5%；P<；.001)明显高于深部毛细血管网(DCN)。SCN半径1 mm处的血流面积小于DCN。浅中心凹无血流区(SFAZ)大小与中心凹SCN的VD值呈负相关，而深FAZ区(DFAZ)的大小与VD值及中心凹血流面积无相关性。结论：OCTA可作为一种无创、可重复、无层的方法，用于定量评价VD和黄斑区血流。血管丛密度和血流量的正常值有助于更好地了解视网膜血管疾病的病理生理学基础。
BACKGROUND AND OBJECTIVE: The quantification of the density of macular vascular networks and blood flow areas in the foveal and parafoveal area in healthy subjects using optical coherence tomography angiography (OCTA).PATIENTS AND METHODS: Cross-sectional, prospective study in an institutional setting at the Retina Services of Farabi Eye Hospital. One hundred twelve normal volunteers with no known ocular or systemic disease were included, including patient numbers (one or both eyes), selection procedures, inclusion/exclusion criteria, randomization procedure, and masking. En face angiogram OCTA was performed on a 3 mm x 3 mm region centered on the macula. Automated thresholding and measuring algorithm method for foveal and parafoveal blood flow and vascular density (VD) were used. The density of macular vascular networks and blood flow area in the foveal and parafoveal area were measured.RESULTS: A total of 224 healthy eyes from 112 subjects with a mean age of 36.4 years +/- 11.3 years were included. In the foveal region, the VD of the superficial capillary network (sCN) was significantly higher than that of the deep capillary network (dCN) (31.1% +/- 5.5% vs. 28.3% +/- 7.2%; P < .001), whereas in the parafoveal area, VD was higher in the dCN (62.24% +/- 2.8% vs. 56.5% +/- 2.5%; P < .001). Flow area in the 1-mm radius circle in the sCN was less than in the dCN. Superficial foveal avascular zone (sFAZ) size was negatively correlated with the VD of the foveal sCN, but in the deep FAZ (dFAZ) was not correlated with VD or blood flow area of the fovea. There was no difference between measured VD and blood flow surface area in both eyes of the subjects.CONCLUSIONS: OCTA could be used as a noninvasive, repeatable, layer-free method in quantitative evaluation of VD and blood flow of macular area. The normal quantities of the vascular plexus density and flow will help in better understanding the pathophysiological basis of the vascular disease of retina.